UNASSIGNED: We collected oral mucosal samples from 49 patients and 10 healthy individuals and conducted 16S rRNA and ITS gene sequencing to explore the oral fungal and bacterial communities.
UNASSIGNED: We observed significantly lower α diversity of fungi in the EOLP group, with Candida being significantly enriched as the main dominant genus. In the NEOLP group, Aspergillaceae were significantly enriched. The EOLP group showed significant enrichment of Aggregatibacter and Lactobacillus, but the relative abundance of Streptococcus was notably lower than in the other two groups. In the NEOLP group, two species including Prevotella intermedia were significantly enriched. The microbial co-occurrence and co-exclusion networks display distinct characteristics across the three groups, with Lactobacillus assuming a significant bridging role in the ELOP group.
UNASSIGNED: Our study indicates that EOLP and NEOLP experience varying degrees of dysbiosis at both the fungal and bacterial levels. Therefore, the pathogenic mechanisms and interactive relationships of these microbiota associated with OLP merit further in-depth investigation.
The microbial community in the oral lesions of EOLP patients exhibits highly distinctive features, both in terms of bacteria and fungi.In NEOLP patients, the overall bacterial composition does not exhibit significant differences compared to the healthy population, but P. intermedia and Aspergillaceae are notably enriched.
■我们收集了49名患者和10名健康个体的口腔粘膜样本,并进行了16SrRNA和ITS基因测序,以探索口腔真菌和细菌群落。
■我们观察到EOLP组真菌的α多样性明显降低,念珠菌作为主要的优势属显著富集。在NEOLP组,曲霉科显著富集。EOLP组显着富集了Aggregatibacter和乳酸杆菌,但链球菌的相对丰度明显低于其他两组。在NEOLP组,包括中间Prevotella在内的两个物种显着富集。微生物共现和共排斥网络在三组中显示出不同的特征,乳杆菌在ELOP组中具有重要的桥接作用。
■我们的研究表明,EOLP和NEOLP在真菌和细菌水平上都经历了不同程度的生态失调。因此,这些微生物群与OLP相关的致病机制和互动关系值得进一步深入研究。
EOLP患者口腔病变中的微生物群落表现出高度鲜明的特征,就细菌和真菌而言。在NEOLP患者中,与健康人群相比,总体细菌组成没有显着差异,但中间假单胞菌和曲霉科明显富集。