PDF(Pubmed)
Abstract：
UNASSIGNED: Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood.
UNASSIGNED: We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics samples were collected from 52 well-characterized participants before, during, and three months after a nine-day inquiry-based stress reduction program.
UNASSIGNED: We found that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.
UNASSIGNED: Our findings reveal a protective link between the Prevotella-dominant microbiome and depression, associated with a less inflammatory environment and moderated symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, highlight potential avenues for microbiome-targeted therapies in depression management.
UNASSIGNED: We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics samples were collected from 52 well-characterized participants before, during, and three months after a nine-day inquiry-based stress reduction program.
UNASSIGNED: We found that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.
UNASSIGNED: Our findings reveal a protective link between the Prevotella-dominant microbiome and depression, associated with a less inflammatory environment and moderated symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, highlight potential avenues for microbiome-targeted therapies in depression management.
摘要：
■抑郁症是全球残疾的主要原因，但其潜在因素，特别是微生物协会，知之甚少。
■我们研究了在沉浸式心理社会干预期间，在抑郁症的背景下，微生物组和免疫系统之间的纵向相互作用。从52个特征明确的参与者那里收集了142个多组学样本，during,以及为期9天的基于调查的减压计划三个月后。
■我们发现抑郁症与推定致病菌的存在增加和微生物β-多样性降低有关。干预之后,我们观察到神经炎症细胞因子的减少和若干心理健康指标的改善.有趣的是,普雷沃氏菌为主的微生物组的参与者在抑郁时表现出轻微的症状，随着更有弹性的微生物组和更有利的炎症细胞因子谱，包括降低的CXCL-1水平。
■我们的发现揭示了普雷沃氏菌为主的微生物组和抑郁症之间的保护性联系，与较少的炎症环境和缓解症状相关。这些见解,再加上观察到的干预措施改善了神经炎症标志物和心理健康，强调在抑郁症管理中微生物组靶向治疗的潜在途径。
■我们研究了在沉浸式心理社会干预期间，在抑郁症的背景下，微生物组和免疫系统之间的纵向相互作用。从52个特征明确的参与者那里收集了142个多组学样本，during,以及为期9天的基于调查的减压计划三个月后。
■我们发现抑郁症与推定致病菌的存在增加和微生物β-多样性降低有关。干预之后,我们观察到神经炎症细胞因子的减少和若干心理健康指标的改善.有趣的是,普雷沃氏菌为主的微生物组的参与者在抑郁时表现出轻微的症状，随着更有弹性的微生物组和更有利的炎症细胞因子谱，包括降低的CXCL-1水平。
■我们的发现揭示了普雷沃氏菌为主的微生物组和抑郁症之间的保护性联系，与较少的炎症环境和缓解症状相关。这些见解,再加上观察到的干预措施改善了神经炎症标志物和心理健康，强调在抑郁症管理中微生物组靶向治疗的潜在途径。
