%0 Journal Article
%T Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program.
%A Zhou X
%A Ganz AB
%A Rayner A
%A Cheng TY
%A Oba H
%A Rolnik B
%A Lancaster S
%A Lu X
%A Li Y
%A Johnson JS
%A Hoyd R
%A Spakowicz DJ
%A Slavich GM
%A Snyder MP
%J bioRxiv
%V 0
%N 0
%D 2024 Jun 27
%M 38979211
暂无%R 10.1101/2024.06.26.600881
%X <B>UNASSIGNED: </B>Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood.<BR><B>UNASSIGNED: </B>We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics samples were collected from 52 well-characterized participants before, during, and three months after a nine-day inquiry-based stress reduction program.<BR><B>UNASSIGNED: </B>We found that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.<BR><B>UNASSIGNED: </B>Our findings reveal a protective link between the Prevotella-dominant microbiome and depression, associated with a less inflammatory environment and moderated symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, highlight potential avenues for microbiome-targeted therapies in depression management.