PDF(Pubmed)
Abstract：
Background Percutaneous nephrolithotomy (PCNL) is considered a standard treatment option for large-size renal stones but is associated with drawbacks such as bleeding and prolonged recovery. Mini-PCNL offers a less invasive alternative, but its efficacy compared to standard PCNL for renal stones larger than 2 cm remains under debate. This study aims to compare the efficacy and safety of standard PCNL versus mini-PCNL for renal stone sizes more than 2 cm. Methods This single-centre prospective interventional study will be conducted at Acharya Vinoba Bhave Rural Hospital (AVBRH). The study will include patients 18 to 70 years of age undergoing unilateral PCNL for renal calculi. Patients with renal stones larger than 2 cm will be enrolled. Data on stone-free rate (SFR), operative duration, hospital stay time, surgical site infection, haemoglobin (Hb) drop, need for blood transfusion, and post-surgery fever will be collected and compared between the two procedures. Statistical analysis of data will be performed using descriptive and analytical statistics. Results The study aims to enrol a total of 32 patients. Data analysis will be done using IBM SPSS Statistics for Windows, Version 24 (Released 2016; IBM Corp., Armonk, New York). Conclusion This study will provide valuable insights into the comparative outcome in terms of efficacy and safety of standard PCNL and mini-PCNL for kidney stones larger than 2 cm.
摘要：
背景经皮肾镜取石术（PCNL）被认为是大尺寸肾结石的标准治疗选择，但存在出血和恢复时间延长等缺点。Mini-PCNL提供了一种侵入性较小的替代方案，但与标准PCNL相比，其对大于2厘米的肾结石的疗效仍存在争议。本研究旨在比较标准PCNL与微型PCNL对2厘米以上肾结石的疗效和安全性。方法这项单中心前瞻性介入研究将在阿查亚·维诺巴·巴韦乡村医院（AVBRH）进行。该研究将包括18至70岁接受单侧PCNL治疗肾结石的患者。肾结石大于2厘米的患者将被纳入。无石率(SFR)数据，手术持续时间,住院时间,手术部位感染,血红蛋白（Hb）下降，需要输血,手术后的发烧将被收集并在两个程序之间进行比较。将使用描述性和分析性统计进行数据的统计分析。结果本研究共纳入32例患者。数据分析将使用IBMSPSSStatisticsforWindows，版本24（2016年发布；IBMCorp.,Armonk,纽约）。结论这项研究将为标准PCNL和mini-PCNL治疗大于2cm的肾结石的疗效和安全性方面的比较结果提供有价值的见解。
