Abstract：
BACKGROUND: Congenital uterine anomalies include a wide diversity of uterine malformations that can compromise reproductive potential. Uterus transplantation (UTx) proposes an innovative treatment for absolute uterine factor infertility; however, there is a lack of standardized protocols to guide clinical management among this population.
OBJECTIVE: To describe recipient and donor characteristics and obstetric outcomes in patients undergoing UTx.
METHODS: We performed a literature search using the PubMed database to retrieve available scientific articles. We analyzed the references of included articles to assess additional articles that could be eligible to be included in the review. Likewise, we identified further studies using other methods, including Google Scholar.
METHODS: Titles and abstracts were screened in duplicate to select original reports with information available for the outcomes of interest.
METHODS: This review assessed the advantages and disadvantages of the techniques used, patient characteristics, obstetric and non-obstetric complications, functional duration of the organ, and neonatal outcomes.
RESULTS: Among the 36 reports included in this review we found 55 pregnancies and 38 live births following UTx and a higher success rate for in vivo uterine donations. The most common obstetric complications reported included miscarriage, pre-eclampsia, and gestational hypertension. The most common non-obstetric complications reported include episodes of rejection, acute kidney injury, anemia, and cholestasis. Living donors required a comprehensive preoperative workup, decreasing organ rejection, infection, and vascular complications.
CONCLUSIONS: More studies are needed to standardize the UTx procedure and improve obstetric, fetal, and neonatal outcomes. Further understanding of which recipient and donor characteristics minimize complications will significantly decrease the risk of adverse outcomes.
OBJECTIVE: To describe recipient and donor characteristics and obstetric outcomes in patients undergoing UTx.
METHODS: We performed a literature search using the PubMed database to retrieve available scientific articles. We analyzed the references of included articles to assess additional articles that could be eligible to be included in the review. Likewise, we identified further studies using other methods, including Google Scholar.
METHODS: Titles and abstracts were screened in duplicate to select original reports with information available for the outcomes of interest.
METHODS: This review assessed the advantages and disadvantages of the techniques used, patient characteristics, obstetric and non-obstetric complications, functional duration of the organ, and neonatal outcomes.
RESULTS: Among the 36 reports included in this review we found 55 pregnancies and 38 live births following UTx and a higher success rate for in vivo uterine donations. The most common obstetric complications reported included miscarriage, pre-eclampsia, and gestational hypertension. The most common non-obstetric complications reported include episodes of rejection, acute kidney injury, anemia, and cholestasis. Living donors required a comprehensive preoperative workup, decreasing organ rejection, infection, and vascular complications.
CONCLUSIONS: More studies are needed to standardize the UTx procedure and improve obstetric, fetal, and neonatal outcomes. Further understanding of which recipient and donor characteristics minimize complications will significantly decrease the risk of adverse outcomes.
摘要：
背景：先天性子宫畸形包括多种可能损害生殖潜能的子宫畸形。子宫移植（UTx）为绝对子宫因素不孕症提出了一种创新的治疗方法；然而，在这一人群中,缺乏指导临床管理的标准化方案.
目的：描述接受UTx的患者的受者和供者特征以及产科结局。
方法：我们使用PubMed数据库进行了文献检索，以检索可用的科学文章。我们分析了纳入文章的参考文献，以评估可能有资格纳入审查的其他文章。同样，我们确定了使用其他方法的进一步研究，包括谷歌学者。
方法：对标题和摘要进行一式两份筛选，以选择原始报告，其中包含感兴趣结果的可用信息。
方法：这篇综述评估了所用技术的优缺点，患者特征,产科和非产科并发症，器官的功能持续时间，和新生儿结局。
结果：在纳入本综述的36份报告中，我们发现了55例妊娠和38例UTx后活产，体内子宫捐献的成功率更高。报告的最常见产科并发症包括流产，先兆子痫,和妊娠高血压。报告的最常见的非产科并发症包括排斥反应，急性肾损伤，贫血,和胆汁淤积。活体捐献者需要全面的术前检查,减少器官排斥，感染,血管并发症。
结论：需要更多的研究来标准化UTx程序并改善产科，胎儿,和新生儿结局。进一步了解哪些受体和供体特征可最大程度地减少并发症，将显着降低不良后果的风险。
目的：描述接受UTx的患者的受者和供者特征以及产科结局。
方法：我们使用PubMed数据库进行了文献检索，以检索可用的科学文章。我们分析了纳入文章的参考文献，以评估可能有资格纳入审查的其他文章。同样，我们确定了使用其他方法的进一步研究，包括谷歌学者。
方法：对标题和摘要进行一式两份筛选，以选择原始报告，其中包含感兴趣结果的可用信息。
方法：这篇综述评估了所用技术的优缺点，患者特征,产科和非产科并发症，器官的功能持续时间，和新生儿结局。
结果：在纳入本综述的36份报告中，我们发现了55例妊娠和38例UTx后活产，体内子宫捐献的成功率更高。报告的最常见产科并发症包括流产，先兆子痫,和妊娠高血压。报告的最常见的非产科并发症包括排斥反应，急性肾损伤，贫血,和胆汁淤积。活体捐献者需要全面的术前检查,减少器官排斥，感染,血管并发症。
结论：需要更多的研究来标准化UTx程序并改善产科，胎儿,和新生儿结局。进一步了解哪些受体和供体特征可最大程度地减少并发症，将显着降低不良后果的风险。
