Abstract：
OBJECTIVE: To determine the sensitivity and specificity of intact parathyroid hormone (iPTH) levels in predicting hypocalcaemia after thyroidectomy.
METHODS: A descriptive cross-sectional study. Place and Duration of the Study: Department of General Surgery, Shifa International Hospital and Shifa Foundation, Islamabad, from May 2021 to 2022.
METHODS: The sample size was calculated to be 205 with consecutive non-probability sampling. Serum iPTH levels and serum calcium levels were measured postoperatively at 6 hours and 24 hours and recorded in a proforma for analysis. After collection, the data were entered and analysed using SPSS version 24.0.
RESULTS: Among 205 patients, 157 (76.6%) were females and 48 (23.4%) were males. At 6 hours postoperatively, 121 (59%) patients had normal iPTH levels and 123 (60%) patients had normal serum calcium levels (p = 0.15). At 24-hour, 130 (63.4%) patients had normal iPTH levels and 92 (44.9%) patients had normal serum calcium levels (p = 0.001). Overall, 8 (3.9%) patients developed symptomatic hypocalcaemia (p = <0.001). The sensitivity and specificity of iPTH levels at ≤15 pg/ml were 100% and 70%, respectively, but at 24 pg/ml cut-off level, the specificity increased to 90% with sensitivity of 100%.
CONCLUSIONS: Low serum iPTH levels at 6 hours after surgery can predict hypocalcaemia in patients undergoing thyroidectomy, even if serum calcium levels appear normal at that time.
BACKGROUND: Parathyroid hormone, Serum calcium, Hypocalcaemia, Total thyroidectomy, Calcium homeostasis.
METHODS: A descriptive cross-sectional study. Place and Duration of the Study: Department of General Surgery, Shifa International Hospital and Shifa Foundation, Islamabad, from May 2021 to 2022.
METHODS: The sample size was calculated to be 205 with consecutive non-probability sampling. Serum iPTH levels and serum calcium levels were measured postoperatively at 6 hours and 24 hours and recorded in a proforma for analysis. After collection, the data were entered and analysed using SPSS version 24.0.
RESULTS: Among 205 patients, 157 (76.6%) were females and 48 (23.4%) were males. At 6 hours postoperatively, 121 (59%) patients had normal iPTH levels and 123 (60%) patients had normal serum calcium levels (p = 0.15). At 24-hour, 130 (63.4%) patients had normal iPTH levels and 92 (44.9%) patients had normal serum calcium levels (p = 0.001). Overall, 8 (3.9%) patients developed symptomatic hypocalcaemia (p = <0.001). The sensitivity and specificity of iPTH levels at ≤15 pg/ml were 100% and 70%, respectively, but at 24 pg/ml cut-off level, the specificity increased to 90% with sensitivity of 100%.
CONCLUSIONS: Low serum iPTH levels at 6 hours after surgery can predict hypocalcaemia in patients undergoing thyroidectomy, even if serum calcium levels appear normal at that time.
BACKGROUND: Parathyroid hormone, Serum calcium, Hypocalcaemia, Total thyroidectomy, Calcium homeostasis.
摘要：
目的：确定完整甲状旁腺激素（iPTH）水平预测甲状腺切除术后低钙血症的敏感性和特异性。
方法：描述性横断面研究。研究的地点和持续时间：普外科，希法国际医院和希法基金会，伊斯兰堡,从2021年5月到2022年。
方法：使用连续的非概率抽样，计算样本量为205。在术后6小时和24小时测量血清iPTH水平和血清钙水平,并记录在形式中用于分析。收集后,使用SPSS24.0版输入和分析数据。
结果：在205名患者中，女性为157（76.6％），男性为48（23.4％）。术后6小时，121例（59％）患者的iPTH水平正常，123例（60％）患者的血清钙水平正常（p=0.15）。24小时,130例（63.4％）患者的iPTH水平正常，92例（44.9％）患者的血清钙水平正常（p=0.001）。总的来说,8例(3.9%)患者出现症状性低钙血症(p=<0.001)。iPTH水平在≤15pg/ml时的敏感性和特异性分别为100%和70%,分别,但在24pg/ml的截止水平，特异性提高到90%,灵敏度为100%.
结论：术后6小时血清iPTH水平低可以预测甲状腺切除术患者的低钙血症，即使当时血清钙水平正常。
背景：甲状旁腺激素，血清钙，低钙血症,全甲状腺切除术,钙稳态。
方法：描述性横断面研究。研究的地点和持续时间：普外科，希法国际医院和希法基金会，伊斯兰堡,从2021年5月到2022年。
方法：使用连续的非概率抽样，计算样本量为205。在术后6小时和24小时测量血清iPTH水平和血清钙水平,并记录在形式中用于分析。收集后,使用SPSS24.0版输入和分析数据。
结果：在205名患者中，女性为157（76.6％），男性为48（23.4％）。术后6小时，121例（59％）患者的iPTH水平正常，123例（60％）患者的血清钙水平正常（p=0.15）。24小时,130例（63.4％）患者的iPTH水平正常，92例（44.9％）患者的血清钙水平正常（p=0.001）。总的来说,8例(3.9%)患者出现症状性低钙血症(p=<0.001)。iPTH水平在≤15pg/ml时的敏感性和特异性分别为100%和70%,分别,但在24pg/ml的截止水平，特异性提高到90%,灵敏度为100%.
结论：术后6小时血清iPTH水平低可以预测甲状腺切除术患者的低钙血症，即使当时血清钙水平正常。
背景：甲状旁腺激素，血清钙，低钙血症,全甲状腺切除术,钙稳态。
