Abstract：
OBJECTIVE: To assess the effectiveness of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser 1064 nm in the management of onychomycosis.
METHODS: Descriptive observational study. Place and Duration of the Study: Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan, from December 2022 to May 2023.
METHODS: Thirty patients, of either gender, aged between 20 and 60 years, with a clinical diagnosis and a positive KOH test for onychomycosis. Long-pulsed 1064-nm Nd:YAG laser therapy was administered to patients. On the basis of nail plate thickness, laser therapy was given once a week for a month at a speed of 25 mm/sec and a spot diameter of 4 mm, with fluencies ranging from 40 - 60 J/cm2. Before and six months\' post-treatment, the patients\' photos were taken and were evaluated based on dermoscopic results and clinical improvement.
RESULTS: The patients\' average age was 40.20 ± 15.85 years, and their average duration of disease was 3.0 ± 1.41 years. Six (20%) were males and 24 (80%) cases were females. The most prevalent clinical type was distolateral subungual onychomycosis 22 (73%). Fourteen (46.6%) cases showed excellent improvement, 6 (20%) cases showed good improvement, and 10 (33.3%) cases showed mild improvement.
CONCLUSIONS: Long-pulsed Nd:YAG laser is a safe and efficient option for onychomycosis because of its high clinical cure rates, lack of side effects, and clinical therapeutic efficacy.
BACKGROUND: Onychomycosis, Nd:YAG laser 1064-nm, Dermatology, Nail, Lasers in dermatology.
METHODS: Descriptive observational study. Place and Duration of the Study: Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan, from December 2022 to May 2023.
METHODS: Thirty patients, of either gender, aged between 20 and 60 years, with a clinical diagnosis and a positive KOH test for onychomycosis. Long-pulsed 1064-nm Nd:YAG laser therapy was administered to patients. On the basis of nail plate thickness, laser therapy was given once a week for a month at a speed of 25 mm/sec and a spot diameter of 4 mm, with fluencies ranging from 40 - 60 J/cm2. Before and six months\' post-treatment, the patients\' photos were taken and were evaluated based on dermoscopic results and clinical improvement.
RESULTS: The patients\' average age was 40.20 ± 15.85 years, and their average duration of disease was 3.0 ± 1.41 years. Six (20%) were males and 24 (80%) cases were females. The most prevalent clinical type was distolateral subungual onychomycosis 22 (73%). Fourteen (46.6%) cases showed excellent improvement, 6 (20%) cases showed good improvement, and 10 (33.3%) cases showed mild improvement.
CONCLUSIONS: Long-pulsed Nd:YAG laser is a safe and efficient option for onychomycosis because of its high clinical cure rates, lack of side effects, and clinical therapeutic efficacy.
BACKGROUND: Onychomycosis, Nd:YAG laser 1064-nm, Dermatology, Nail, Lasers in dermatology.
摘要：
目的：评估掺钕钇铝石榴石（Nd：YAG）1064nm激光治疗甲癣的有效性。
方法：描述性观察研究。研究的地点和持续时间：皮肤科，PNSShifa医院,卡拉奇,巴基斯坦,从2022年12月到2023年5月。
方法：30名患者，无论男女，年龄在20至60岁之间，甲癣的临床诊断和KOH检测呈阳性。对患者进行长脉冲1064-nmNd:YAG激光治疗。在钉板厚度的基础上，激光治疗每周一次，以25毫米/秒的速度和4毫米的斑点直径进行一个月，与通量范围从40-60J/cm2。治疗前和治疗后六个月，根据皮肤镜结果和临床改善情况对患者进行拍照和评估。
结果：患者的平均年龄为40.20±15.85岁，他们的平均病程为3.0±1.41年。6例（20％）为男性，24例（80％）为女性。最常见的临床类型是甲外侧甲癣22（73％）。14例(46.6%)改善良好,6例(20%)表现出良好的改善，10例（33.3％）显示轻度改善。
结论：长脉冲Nd:YAG激光治疗甲癣安全有效，临床治愈率高，没有副作用,和临床治疗效果。
背景：甲癣，Nd:YAG激光器1064-nm,皮肤科,钉,皮肤病学中的激光。
方法：描述性观察研究。研究的地点和持续时间：皮肤科，PNSShifa医院,卡拉奇,巴基斯坦,从2022年12月到2023年5月。
方法：30名患者，无论男女，年龄在20至60岁之间，甲癣的临床诊断和KOH检测呈阳性。对患者进行长脉冲1064-nmNd:YAG激光治疗。在钉板厚度的基础上，激光治疗每周一次，以25毫米/秒的速度和4毫米的斑点直径进行一个月，与通量范围从40-60J/cm2。治疗前和治疗后六个月，根据皮肤镜结果和临床改善情况对患者进行拍照和评估。
结果：患者的平均年龄为40.20±15.85岁，他们的平均病程为3.0±1.41年。6例（20％）为男性，24例（80％）为女性。最常见的临床类型是甲外侧甲癣22（73％）。14例(46.6%)改善良好,6例(20%)表现出良好的改善，10例（33.3％）显示轻度改善。
结论：长脉冲Nd:YAG激光治疗甲癣安全有效，临床治愈率高，没有副作用,和临床治疗效果。
背景：甲癣，Nd:YAG激光器1064-nm,皮肤科,钉,皮肤病学中的激光。
