METHODS: The study included 216 ALS patients. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and smell identification test specifically for the Chinese population (CSIT) were administered to evaluate participants\' cognitive and olfactory function, respectively.
RESULTS: After covarying for age, sex, BMI, education level, degree of hunger, dietary bias, eagerness for food, stress, smoking status, alcohol consumption, and upper respiratory tract infection (URTI) or rhinitis, CSIT scores were significantly correlated with ECAS scores (r = 0.162, p = 0.028), especially the ALS-specific scores (r = 0.158, p = 0.031). Even after excluding patients with URTI or rhinitis, the results were similar. CSIT scores were significantly correlated with ECAS scores (r = 0.224, p = 0.011), especially the ALS-specific scores (r = 0.205, p = 0.019).
CONCLUSIONS: In patients with ALS, smell loss is significantly correlated with cognitive impairment, particularly frontotemporal dysfunction. Cognitive dysfunction may lead to worse olfactory performance in ALS patients.
方法:该研究包括216名ALS患者。爱丁堡认知和行为ALS筛查(ECAS)和专门针对中国人群的嗅觉识别测试(CSIT)进行了评估参与者的认知和嗅觉功能,分别。
结果:在考虑年龄因素后,性别,BMI,教育水平,饥饿程度,饮食偏见,渴望食物,压力,吸烟状况,酒精消费,和上呼吸道感染(URTI)或鼻炎,CSIT得分与ECAS得分显著相关(r=0.162,p=0.028),尤其是ALS特异性评分(r=0.158,p=0.031)。即使排除URTI或鼻炎患者,结果相似。CSIT得分与ECAS得分显著相关(r=0.224,p=0.011),尤其是ALS特异性评分(r=0.205,p=0.019)。
结论:在ALS患者中,嗅觉丧失与认知障碍显著相关,尤其是额颞叶功能障碍。认知功能障碍可能导致ALS患者嗅觉表现变差。