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Abstract：
BACKGROUND: When common mental disorders (CMD) co-occur with HIV/AIDS, they can complicate patient diagnosis, help-seeking behaviors, quality of life, treatment outcomes, and drug adherence. Thus, estimating the pooled prevalence of CMD and its association with perceived stigma and social support among people living with HIV/AIDS (PLWHA) in Ethiopia could potentially support policymakers and health professionals to understand the disease burden and set a solution to improve the mental well-being of PLWHA.
METHODS: Popular databases such as PubMed, SCOPUS, EMBASE, and Psych-INFO as well as Google Scholar, AJOL, CINAHL, PILOTS and Web of Science were searched for the relevant articles conducted in Ethiopia. We included cross-sectional, case-control, and cohort studies in the review. The Comprehensive Meta-Analysis software version 3.0 was used to pool the results of the included studies. The Q- and I2-statistics were used to assess the heterogeneity between the included studies. We employed a random-effects meta-analysis model to estimate the pooled prevalence of CMD and to account for heterogeneity among the included studies. We also conducted a leave-one-out analyses, and stratified meta-analyses by gender (male and female).
RESULTS: The studies included in this systematic review and meta-analysis were published between 2009 and 2021, recruiting a total of 5625 participants. The pooled estimated prevalence of CMD among PLWHA in Ethiopia was 26.1% (95% CI 18.1-36.0). The pooled estimated prevalence of CMD was significantly higher among females, at 39.5% (95% CI 21.2-39.0), compared to males, 26.9% (95% CI 15.6-31.7). Moreover, the pooled estimated prevalence of CMD in PLWHA ranged from 23.5 to 28.9% in the leave-one-out sensitivity analysis, indicating that the removal of any single study did not significantly affect the pooled estimate. The pooled effects (AOR) of Perceived HIV stigma and poor perceived social support on common mental disorder were 2.91, 95% CI (1.35-6.29) and 5.56, 95% CI (1.89-16.39), respectively.
CONCLUSIONS: People living with HIV/AIDS (PLWHA) who received poor social support and those with HIV-related perceived stigma were found to have strong association with CMD. Therefore, it is advisable that all PLWHA attending ART clinic should be screened for CMD, social support and HIV-related perceived stigma.
METHODS: Popular databases such as PubMed, SCOPUS, EMBASE, and Psych-INFO as well as Google Scholar, AJOL, CINAHL, PILOTS and Web of Science were searched for the relevant articles conducted in Ethiopia. We included cross-sectional, case-control, and cohort studies in the review. The Comprehensive Meta-Analysis software version 3.0 was used to pool the results of the included studies. The Q- and I2-statistics were used to assess the heterogeneity between the included studies. We employed a random-effects meta-analysis model to estimate the pooled prevalence of CMD and to account for heterogeneity among the included studies. We also conducted a leave-one-out analyses, and stratified meta-analyses by gender (male and female).
RESULTS: The studies included in this systematic review and meta-analysis were published between 2009 and 2021, recruiting a total of 5625 participants. The pooled estimated prevalence of CMD among PLWHA in Ethiopia was 26.1% (95% CI 18.1-36.0). The pooled estimated prevalence of CMD was significantly higher among females, at 39.5% (95% CI 21.2-39.0), compared to males, 26.9% (95% CI 15.6-31.7). Moreover, the pooled estimated prevalence of CMD in PLWHA ranged from 23.5 to 28.9% in the leave-one-out sensitivity analysis, indicating that the removal of any single study did not significantly affect the pooled estimate. The pooled effects (AOR) of Perceived HIV stigma and poor perceived social support on common mental disorder were 2.91, 95% CI (1.35-6.29) and 5.56, 95% CI (1.89-16.39), respectively.
CONCLUSIONS: People living with HIV/AIDS (PLWHA) who received poor social support and those with HIV-related perceived stigma were found to have strong association with CMD. Therefore, it is advisable that all PLWHA attending ART clinic should be screened for CMD, social support and HIV-related perceived stigma.
摘要：
背景：当常见精神障碍（CMD）与HIV/AIDS同时发生时，它们会使病人的诊断复杂化,寻求帮助的行为，生活质量,治疗结果，和药物依从性。因此，评估埃塞俄比亚HIV/AIDS患者(PLWHA)中CMD的合并患病率及其与感知到的污名和社会支持的关联,有可能支持政策制定者和卫生专业人员了解疾病负担,并为改善PLWHA的心理健康制定解决方案.
方法：流行的数据库，如PubMed、Scopus,EMBASE,和心理信息以及谷歌学者，AJOL,CINAHL,搜索了PILOTS和WebofScience在埃塞俄比亚进行的相关文章。我们包括横截面，病例控制，和队列研究。使用综合荟萃分析软件3.0版汇集纳入研究的结果。使用Q和I2统计量评估纳入研究之间的异质性。我们采用随机效应荟萃分析模型来估计CMD的合并患病率，并解释纳入研究的异质性。我们还进行了留一法分析，并按性别（男性和女性）进行分层荟萃分析。
结果：本系统综述和荟萃分析中包含的研究发表于2009年至2021年之间，共招募了5625名参与者。埃塞俄比亚PLWHA中CMD的汇总估计患病率为26.1％（95％CI18.1-36.0）。CMD的汇总估计患病率在女性中明显更高，39.5%（95%CI21.2-39.0），与男性相比，26.9%（95%CI15.6-31.7）。此外，在留一敏感性分析中，PLWHA中CMD的汇总估计患病率为23.5％至28.9％，这表明删除任何一项研究对汇总估计值没有显著影响.感知到的HIV污名和感知到的不良社会支持对常见精神障碍的综合影响（AOR）为2.91，95％CI（1.35-6.29）和5.56，95％CI（1.89-16.39），分别。
结论：发现接受不良社会支持的HIV/AIDS患者（PLWHA）和与HIV相关的病耻感患者与CMD密切相关。因此,建议对所有参加ART诊所的PLWHA进行CMD筛查，社会支持和艾滋病毒相关的耻辱。
方法：流行的数据库，如PubMed、Scopus,EMBASE,和心理信息以及谷歌学者，AJOL,CINAHL,搜索了PILOTS和WebofScience在埃塞俄比亚进行的相关文章。我们包括横截面，病例控制，和队列研究。使用综合荟萃分析软件3.0版汇集纳入研究的结果。使用Q和I2统计量评估纳入研究之间的异质性。我们采用随机效应荟萃分析模型来估计CMD的合并患病率，并解释纳入研究的异质性。我们还进行了留一法分析，并按性别（男性和女性）进行分层荟萃分析。
结果：本系统综述和荟萃分析中包含的研究发表于2009年至2021年之间，共招募了5625名参与者。埃塞俄比亚PLWHA中CMD的汇总估计患病率为26.1％（95％CI18.1-36.0）。CMD的汇总估计患病率在女性中明显更高，39.5%（95%CI21.2-39.0），与男性相比，26.9%（95%CI15.6-31.7）。此外，在留一敏感性分析中，PLWHA中CMD的汇总估计患病率为23.5％至28.9％，这表明删除任何一项研究对汇总估计值没有显著影响.感知到的HIV污名和感知到的不良社会支持对常见精神障碍的综合影响（AOR）为2.91，95％CI（1.35-6.29）和5.56，95％CI（1.89-16.39），分别。
结论：发现接受不良社会支持的HIV/AIDS患者（PLWHA）和与HIV相关的病耻感患者与CMD密切相关。因此,建议对所有参加ART诊所的PLWHA进行CMD筛查，社会支持和艾滋病毒相关的耻辱。
