PDF(Pubmed)
Abstract：
BACKGROUND: The link between diabetes mellitus and chronic hepatitis C infection remains well established. It is estimated that up to one third of chronic hepatitis C patients have type II diabetes mellitus. Hepatitis C virus infection is one of the main global health burdens. Sofosbuvir and Daclatasvir are used as effective antiviral inhibitors of hepatitis C virus. The cardiovascular effects of those drugs are not well studied. We used electrocardiography and echocardiography with global longitudinal strain assessment by speckle tracking to detect their effect on cardiac function.
RESULTS: One hundred diabetic patients with hepatitis C infection were included in the study. Abdominal ultrasound and laboratory work up were carried out for all participants. Left ventricular systolic and diastolic function were assessed by 2D-echocardiography and global longitudinal strain, before and 3 months after treatment. Results showed significant decrease in global longitudinal strain 3 months after therapy (-21 ± 4 vs. -18 ± 7; P < 0.001) but other echocardiographic findings showed no significant changes.
CONCLUSIONS: Sofosbuvir and Daclatasvir were associated with early left ventricular systolic dysfunction as assessed by global longitudinal strain in diabetic patients. More deterioration in left ventricular systolic function was detected among those with Child-Pough class B. Further long-term follow-up may be required.
RESULTS: One hundred diabetic patients with hepatitis C infection were included in the study. Abdominal ultrasound and laboratory work up were carried out for all participants. Left ventricular systolic and diastolic function were assessed by 2D-echocardiography and global longitudinal strain, before and 3 months after treatment. Results showed significant decrease in global longitudinal strain 3 months after therapy (-21 ± 4 vs. -18 ± 7; P < 0.001) but other echocardiographic findings showed no significant changes.
CONCLUSIONS: Sofosbuvir and Daclatasvir were associated with early left ventricular systolic dysfunction as assessed by global longitudinal strain in diabetic patients. More deterioration in left ventricular systolic function was detected among those with Child-Pough class B. Further long-term follow-up may be required.
摘要：
背景：糖尿病和慢性丙型肝炎感染之间的联系仍然很明确。据估计,多达三分之一的慢性丙型肝炎患者患有II型糖尿病。丙型肝炎病毒感染是全球主要的健康负担之一。Sofosbuvir和Daclatasvir被用作丙型肝炎病毒的有效抗病毒抑制剂。这些药物的心血管作用没有得到很好的研究。我们使用心电图和超声心动图通过斑点追踪评估整体纵向应变来检测它们对心脏功能的影响。
结果：100名丙型肝炎感染的糖尿病患者被纳入研究。对所有参与者进行了腹部超声和实验室检查。通过二维超声心动图和整体纵向应变评估左心室收缩和舒张功能，治疗前和治疗后3个月。结果显示治疗后3个月整体纵向应变显着降低（-21±4vs.-18±7；P<0.001），但其他超声心动图检查结果无明显变化。
结论：Sofosbuvir和Daclatasvir与糖尿病患者的整体纵向应变评估的早期左心室收缩功能障碍有关。在Child-PoughB级患者中，发现左心室收缩功能恶化更多。可能需要进一步的长期随访。
结果：100名丙型肝炎感染的糖尿病患者被纳入研究。对所有参与者进行了腹部超声和实验室检查。通过二维超声心动图和整体纵向应变评估左心室收缩和舒张功能，治疗前和治疗后3个月。结果显示治疗后3个月整体纵向应变显着降低（-21±4vs.-18±7；P<0.001），但其他超声心动图检查结果无明显变化。
结论：Sofosbuvir和Daclatasvir与糖尿病患者的整体纵向应变评估的早期左心室收缩功能障碍有关。在Child-PoughB级患者中，发现左心室收缩功能恶化更多。可能需要进一步的长期随访。
