RESULTS: One hundred diabetic patients with hepatitis C infection were included in the study. Abdominal ultrasound and laboratory work up were carried out for all participants. Left ventricular systolic and diastolic function were assessed by 2D-echocardiography and global longitudinal strain, before and 3 months after treatment. Results showed significant decrease in global longitudinal strain 3 months after therapy (-21 ± 4 vs. -18 ± 7; P < 0.001) but other echocardiographic findings showed no significant changes.
CONCLUSIONS: Sofosbuvir and Daclatasvir were associated with early left ventricular systolic dysfunction as assessed by global longitudinal strain in diabetic patients. More deterioration in left ventricular systolic function was detected among those with Child-Pough class B. Further long-term follow-up may be required.
结果:100名丙型肝炎感染的糖尿病患者被纳入研究。对所有参与者进行了腹部超声和实验室检查。通过二维超声心动图和整体纵向应变评估左心室收缩和舒张功能,治疗前和治疗后3个月。结果显示治疗后3个月整体纵向应变显着降低(-21±4vs.-18±7;P<0.001),但其他超声心动图检查结果无明显变化。
结论:Sofosbuvir和Daclatasvir与糖尿病患者的整体纵向应变评估的早期左心室收缩功能障碍有关。在Child-PoughB级患者中,发现左心室收缩功能恶化更多。可能需要进一步的长期随访。