药理学 Gq 抑制诱导强烈的肺血管舒张并逆转肺动脉高压。
关键词: Gq Inhibition Pulmonary Arterial Hypertension Vasoconstriction
Mesh : Animals GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism antagonists & inhibitors Hypertension, Pulmonary / drug therapy physiopathology Humans Mice Pulmonary Artery / drug effects Myocytes, Smooth Muscle / drug effects metabolism Swine Vasodilation / drug effects Male Cell Proliferation / drug effects Cell Movement / drug effects Mice, Inbred C57BL Depsipeptides
来 源:
DOI:10.1038/s44321-024-00096-0
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