SPRING 通过置换抑制性前结构域来许可 S1P 介导的 SREBP2 裂解。
Mesh : Sterol Regulatory Element Binding Protein 2 / metabolism genetics Humans Protein Domains Serine Endopeptidases / metabolism chemistry genetics Endoplasmic Reticulum / metabolism Cryoelectron Microscopy Golgi Apparatus / metabolism Proprotein Convertases / metabolism genetics Cholesterol / metabolism Animals HEK293 Cells Signal Transduction
来 源:
DOI:10.1038/s41467-024-50068-8
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