Abstract：
OBJECTIVE: This study aimed to assess the efficacy and safety of ballon dilation of the eustachian tube (BDET) in adult population suffering from Eustachian tube dysfunction (ETD).
METHODS: Following PRISMA criteria, a systematic review was conducted by searching PubMed, Cochrane, and Embase databases from January 2015 to March 2024. The primary outcomes included Eustachian Tube Score (ETS), tympanometry, and Valsalva maneuver. The quality of studies was assessed using the Quality in Prognostic Studies (QUIPS) instrument.
RESULTS: Overall, 11 studies were incorporated into the systematic review: two RCTs, three prospective investigations, and six retrospective studies. The balloon dilation in all investigations was performed using either Spiggle & Theis or Acclarent catheters for balloon dilation. There was heterogeneity across studies examining the effect of BDET on persistent ETD in terms of patient selection, period of follow-up, administration of conservative or surgical therapies, and use of assessment methods. Overall, the treatment yielded alleviation of symptoms, which either exhibited stability over time or demonstrated further improvement after an average duration of follow-up. Moreover, the incidence of complications was categorized as low and resolving spontaneously. The majority of the studies exhibited a high risk of bias related to confounding variables, and consequently, the overall risk of bias across most studies was considered high.
CONCLUSIONS: The findings suggest BDET holds promise for ETD treatment, reducing symptom severity with minimal complications. Nonetheless, there is a need for improved studies that adhere to established indications, methodologies, and outcomes to establish a more robust body of evidence.
METHODS: Following PRISMA criteria, a systematic review was conducted by searching PubMed, Cochrane, and Embase databases from January 2015 to March 2024. The primary outcomes included Eustachian Tube Score (ETS), tympanometry, and Valsalva maneuver. The quality of studies was assessed using the Quality in Prognostic Studies (QUIPS) instrument.
RESULTS: Overall, 11 studies were incorporated into the systematic review: two RCTs, three prospective investigations, and six retrospective studies. The balloon dilation in all investigations was performed using either Spiggle & Theis or Acclarent catheters for balloon dilation. There was heterogeneity across studies examining the effect of BDET on persistent ETD in terms of patient selection, period of follow-up, administration of conservative or surgical therapies, and use of assessment methods. Overall, the treatment yielded alleviation of symptoms, which either exhibited stability over time or demonstrated further improvement after an average duration of follow-up. Moreover, the incidence of complications was categorized as low and resolving spontaneously. The majority of the studies exhibited a high risk of bias related to confounding variables, and consequently, the overall risk of bias across most studies was considered high.
CONCLUSIONS: The findings suggest BDET holds promise for ETD treatment, reducing symptom severity with minimal complications. Nonetheless, there is a need for improved studies that adhere to established indications, methodologies, and outcomes to establish a more robust body of evidence.
摘要：
目的：本研究旨在评估咽鼓管球囊扩张（BDET）在患有咽鼓管功能障碍（ETD）的成年人群中的有效性和安全性。
方法：遵循PRISMA标准，通过搜索PubMed进行了系统的审查，科克伦,和Embase数据库从2015年1月到2024年3月。主要结果包括咽鼓管评分(ETS)，鼓室测压,和瓦尔萨尔瓦演习。使用预后研究质量（QUIPS）仪器评估研究质量。
结果：总体而言，11项研究纳入系统评价：两项随机对照试验，三项前瞻性调查，和六项回顾性研究。所有研究中的球囊扩张均使用Spiggle&Theis或Acclarent导管进行球囊扩张。在患者选择方面，研究BDET对持续性ETD的影响存在异质性。随访期,给予保守或手术治疗，以及评估方法的使用。总的来说,治疗缓解了症状，在平均随访时间后表现出稳定性或进一步改善。此外，并发症的发生率被归类为低和自发解决.大多数研究表现出与混杂变量相关的高风险偏倚，因此，大多数研究的总体偏倚风险被认为较高.
结论：研究结果表明，BDET有望治疗ETD，减少症状严重程度，并发症最少。尽管如此，有必要改进坚持既定适应症的研究，方法论，和结果来建立更有力的证据。
方法：遵循PRISMA标准，通过搜索PubMed进行了系统的审查，科克伦,和Embase数据库从2015年1月到2024年3月。主要结果包括咽鼓管评分(ETS)，鼓室测压,和瓦尔萨尔瓦演习。使用预后研究质量（QUIPS）仪器评估研究质量。
结果：总体而言，11项研究纳入系统评价：两项随机对照试验，三项前瞻性调查，和六项回顾性研究。所有研究中的球囊扩张均使用Spiggle&Theis或Acclarent导管进行球囊扩张。在患者选择方面，研究BDET对持续性ETD的影响存在异质性。随访期,给予保守或手术治疗，以及评估方法的使用。总的来说,治疗缓解了症状，在平均随访时间后表现出稳定性或进一步改善。此外，并发症的发生率被归类为低和自发解决.大多数研究表现出与混杂变量相关的高风险偏倚，因此，大多数研究的总体偏倚风险被认为较高.
结论：研究结果表明，BDET有望治疗ETD，减少症状严重程度，并发症最少。尽管如此，有必要改进坚持既定适应症的研究，方法论，和结果来建立更有力的证据。
