Abstract：
Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic respiratory symptoms due to inflammatory and destructive changes of the lung leading to progressive airflow obstruction. Fragility fractures associated with osteoporosis are among major comorbidities and have significant impacts on quality of life and prognosis of patients with COPD. Evidence suggests that both decreased bone mineral density (BMD) and impaired bone quality contribute to bone fragility and resultant fractures in COPD. Although various clinical risk factors of osteoporosis have been described, mechanisms of COPD-associated osteoporosis are still largely unknown. In addition, its specific treatment has not been established, either. Previous studies have suggested involvement of low BMI and sarcopenia in the pathogenesis of COPD-associated osteoporosis. In this narrative review, we will propose critical roles of vitamin D deficiency and inflammation, both of which are often present in COPD and may underlie the development of osteosarcopenia and impaired bone quality, ultimately causing fractures in COPD patients.
摘要：
慢性阻塞性肺疾病（COPD）是一种以慢性呼吸道症状为特征的疾病，由于肺部的炎症和破坏性变化导致进行性气流阻塞。与骨质疏松相关的脆性骨折是主要的合并症，对COPD患者的生活质量和预后有显著影响。有证据表明，骨矿物质密度（BMD）降低和骨质量受损均导致COPD中骨脆性和骨折。尽管已经描述了骨质疏松症的各种临床危险因素，COPD相关骨质疏松的机制在很大程度上还不清楚.此外,其具体待遇尚未确定，要么。先前的研究表明，低BMI和少肌症参与COPD相关骨质疏松症的发病机制。在这篇叙述性评论中，我们将提出维生素D缺乏和炎症的关键作用，两者都经常出现在COPD中，并且可能是骨量减少症的发展和骨质量受损的基础，最终导致COPD患者骨折。
