一种结合伏立诺他和吡罗氏酮 a 的双前药纳米凝胶 , 用于高效光化学疗法。
关键词: Histone deacetylase Histone deacetylase inhibitors Nano Hydrogel Photodynamic therapy Pyropheophorbide a
Mesh : Animals Vorinostat / administration & dosage pharmacology chemistry Photochemotherapy / methods Chlorophyll / analogs & derivatives chemistry administration & dosage pharmacology Serum Albumin, Bovine / chemistry administration & dosage Cell Line, Tumor Nanogels / chemistry Prodrugs / administration & dosage chemistry Mice Apoptosis / drug effects Drug Liberation Antineoplastic Agents / administration & dosage chemistry pharmacology Humans Reactive Oxygen Species / metabolism Photosensitizing Agents / administration & dosage pharmacology chemistry Mice, Inbred C57BL Lung Neoplasms / drug therapy pathology Melanoma, Experimental / drug therapy Polyethyleneimine / chemistry
来 源: DOI:10.1016/j.ijpharm.2024.124422