Abstract：
Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM.
摘要：
脉络膜黑色素瘤（CM），高度转移的眼部肿瘤,表现出缺氧诱导的血管生成拟态（VM）。本研究探讨了抗疟疾药物青蒿琥酯（ART）通过调节HIF-1α/VEGF/PDGF途径对CMVM的抑制作用。免疫组织化学(IHC)证实CM中的VM具有升高的VEGF和PDGF表达。缺氧促进CM增殖，上调HIF-1α，VEGF和PDGF。VEGF和PDGF增强CM迁移，入侵和虚拟机，与HIF-1α起关键作用。ART通过抑制HIF-1α/VEGF/PDGF途径减轻VM形成，突出了其在CM中作为抗肿瘤剂的潜力。
