{Reference Type}: Journal Article
{Title}: Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway.
{Author}: Ma QY;Xu XY;Zhu YZ;Yao NN;Liu YC;Gao XD;Zhang Q;Luo WJ;
{Journal}: Acta Histochem
{Volume}: 126
{Issue}: 5
{Year}: 2024 Jul 7
{Factor}: 2.147
{DOI}: 10.1016/j.acthis.2024.152174
{Abstract}: Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM.