Abstract：
Pueraria lobata (Willd.) Ohwi, known as kudzu and used as a \"longevity powder\" in China, is an edible plant which is rich in flavonoids and believed to be useful for regulating blood sugar and treating diabetes, although the modes of action are unknown. Here, a total of 53 flavonoids including 6 novel compounds were isolated from kudzu using multidimensional preparative liquid chromatography. The flavonoid components were found to lower blood sugar levels, promote urine sugar levels in mice, and reduce the urine volume. Molecular docking and in vitro assays suggested that the antidiabetic effect of kudzu was attributed to at least three targets: sodium-dependent glucose transporter 2 (SGLT2), protein tyrosine phosphatase-1B (PTP1B), and alpha-glucosidase (AG). This study suggests a possible mechanism for the antidiabetic effect that may involve the synergistic action of multiple active compounds from kudzu.
摘要：
葛根(willd.)Ohwi,被称为葛根，在中国被用作“长寿粉”，是一种富含类黄酮的食用植物，被认为对调节血糖和治疗糖尿病有用，虽然行动模式是未知的。这里,利用多维制备液相色谱法从葛根中分离出53种黄酮类化合物，包括6种新化合物。发现类黄酮成分可以降低血糖水平，促进小鼠尿糖水平，减少尿量.分子对接和体外实验表明，葛根的抗糖尿病作用至少归因于三个靶标：钠依赖性葡萄糖转运蛋白2（SGLT2），蛋白酪氨酸磷酸酶-1B（PTP1B），和α-葡糖苷酶(AG)。这项研究表明了抗糖尿病作用的可能机制，该机制可能涉及来自葛根的多种活性化合物的协同作用。
