Abstract：
This review offers a comprehensive analysis of the intricate relationship between the gut virome and diabetes, elucidating the mechanisms by which the virome engages with both human cells and the intestinal bacteriome. By examining a decade of scientific literature, we provide a detailed account of the distinct viral variations observed in type 1 diabetes (T1D) and type 2 diabetes (T2D). Our synthesis reveals that the gut virome significantly influences the development of both diabetes types through its interactions, which indirectly modulate immune and inflammatory responses. In T1D, the focus is on eukaryotic viruses that stimulate the host\'s immune system, whereas T2D is characterized by a broader spectrum of altered phage diversities. Promisingly, in vitro and animal studies suggest fecal virome transplantation as a potential therapeutic strategy to alleviate symptoms of T2D and obesity. This study pioneers a holistic overview of the gut virome\'s role in T1D and T2D, its interplay with host immunity, and the innovative potential of fecal transplantation therapy in clinical diabetes management.
摘要：
这篇综述全面分析了肠道病毒和糖尿病之间的复杂关系。阐明病毒与人类细胞和肠道细菌组的作用机制。通过研究十年的科学文献，我们详细介绍了在1型糖尿病(T1D)和2型糖尿病(T2D)中观察到的不同病毒变异.我们的合成表明，肠道病毒通过其相互作用显着影响两种类型的糖尿病的发展，间接调节免疫和炎症反应。在T1D中,重点是刺激宿主免疫系统的真核病毒，而T2D的特征是更广泛的噬菌体多样性改变。有希望的,体外和动物研究表明粪便病毒移植是缓解T2D和肥胖症状的潜在治疗策略.这项研究开创了肠道病毒在T1D和T2D中的作用的整体概述，它与宿主免疫力的相互作用，以及粪便移植疗法在临床糖尿病管理中的创新潜力。
