Abstract：
BACKGROUND: Patients with organic gastrointestinal (GI) diseases and diabetes mellitus (DM) can have concomitant disorders of gut-brain interaction (DGBI).
OBJECTIVE: This study aimed to compare the global prevalence of DGBI-compatible symptom profiles in adults with and without self-reported organic GI diseases or DM.
METHODS: Data were collected in a population-based internet survey in 26 countries, the Rome Foundation Global Epidemiology Study (n = 54,127). Individuals were asked if they had been diagnosed by a doctor with gastroesophageal reflux disease, peptic ulcer, coeliac disease, inflammatory bowel disease (IBD), diverticulitis, GI cancer or DM. Individuals not reporting the organic diagnosis of interest were included in the reference group. DGBI-compatible symptom profiles were based on Rome IV diagnostic questions. Odds ratios (ORs [95% confidence interval]) were calculated using mixed logistic regression models.
RESULTS: Having one of the investigated organic GI diseases was linked to having any DGBI-compatible symptom profile ranging from OR 1.64 [1.33, 2.02] in GI cancer to OR 3.22 [2.80, 3.69] in IBD. Those associations were stronger than for DM, OR 1.26 [1.18, 1.35]. Strong links between organic GI diseases and DGBI-compatible symptom profiles were seen for corresponding (e.g., IBD and bowel DGBI) and non-corresponding (e.g., IBD and esophageal DGBI) anatomical regions. The strongest link was seen between fecal incontinence and coeliac disease, OR 6.94 [4.95, 9.73]. After adjusting for confounding factors, associations diminished, but persisted.
CONCLUSIONS: DGBI-compatible symptom profiles are more common in individuals with self-reported organic GI diseases and DM compared to the general population. The presence of these concomitant DGBIs should be considered in the management of organic (GI) diseases.
OBJECTIVE: This study aimed to compare the global prevalence of DGBI-compatible symptom profiles in adults with and without self-reported organic GI diseases or DM.
METHODS: Data were collected in a population-based internet survey in 26 countries, the Rome Foundation Global Epidemiology Study (n = 54,127). Individuals were asked if they had been diagnosed by a doctor with gastroesophageal reflux disease, peptic ulcer, coeliac disease, inflammatory bowel disease (IBD), diverticulitis, GI cancer or DM. Individuals not reporting the organic diagnosis of interest were included in the reference group. DGBI-compatible symptom profiles were based on Rome IV diagnostic questions. Odds ratios (ORs [95% confidence interval]) were calculated using mixed logistic regression models.
RESULTS: Having one of the investigated organic GI diseases was linked to having any DGBI-compatible symptom profile ranging from OR 1.64 [1.33, 2.02] in GI cancer to OR 3.22 [2.80, 3.69] in IBD. Those associations were stronger than for DM, OR 1.26 [1.18, 1.35]. Strong links between organic GI diseases and DGBI-compatible symptom profiles were seen for corresponding (e.g., IBD and bowel DGBI) and non-corresponding (e.g., IBD and esophageal DGBI) anatomical regions. The strongest link was seen between fecal incontinence and coeliac disease, OR 6.94 [4.95, 9.73]. After adjusting for confounding factors, associations diminished, but persisted.
CONCLUSIONS: DGBI-compatible symptom profiles are more common in individuals with self-reported organic GI diseases and DM compared to the general population. The presence of these concomitant DGBIs should be considered in the management of organic (GI) diseases.
摘要：
背景：患有器质性胃肠（GI）疾病和糖尿病（DM）的患者可能伴有肠-脑相互作用（DGBI）的疾病。
目的：本研究旨在比较有或没有自我报告的器质性胃肠道疾病或DM的成人中DGBI相容症状的全球患病率。
方法：数据来自26个国家的基于人群的互联网调查，罗马基金会全球流行病学研究(n=54,127)。人们被问及他们是否被医生诊断出患有胃食管反流病，消化性溃疡,乳糜泻,炎症性肠病（IBD），憩室炎,GI癌或DM。未报告感兴趣的有机诊断的个体包括在参照组中。与DGBI兼容的症状概况基于罗马IV诊断问题。使用混合逻辑回归模型计算赔率(OR[95%置信区间])。
结果：患有所研究的器质性GI疾病之一与任何DGBI兼容的症状谱有关，范围从GI癌症的OR1.64[1.33,2.02]到IBD的OR3.22[2.80,3.69]。这些协会比DM强，或1.26[1.18,1.35]。在相应的有机胃肠道疾病和DGBI相容的症状谱之间有很强的联系(例如，IBD和肠道DGBI)和非对应(例如，IBD和食管DGBI）解剖区域。大便失禁和乳糜泻之间的联系最强，或6.94[4.95,9.73]。在调整混杂因素后，协会减少，但坚持。
结论：与DGBI相容的症状谱在患有自我报告的器质性GI疾病和DM的个体中更常见。在有机（GI）疾病的管理中应考虑这些伴随的DGBIs的存在。
目的：本研究旨在比较有或没有自我报告的器质性胃肠道疾病或DM的成人中DGBI相容症状的全球患病率。
方法：数据来自26个国家的基于人群的互联网调查，罗马基金会全球流行病学研究(n=54,127)。人们被问及他们是否被医生诊断出患有胃食管反流病，消化性溃疡,乳糜泻,炎症性肠病（IBD），憩室炎,GI癌或DM。未报告感兴趣的有机诊断的个体包括在参照组中。与DGBI兼容的症状概况基于罗马IV诊断问题。使用混合逻辑回归模型计算赔率(OR[95%置信区间])。
结果：患有所研究的器质性GI疾病之一与任何DGBI兼容的症状谱有关，范围从GI癌症的OR1.64[1.33,2.02]到IBD的OR3.22[2.80,3.69]。这些协会比DM强，或1.26[1.18,1.35]。在相应的有机胃肠道疾病和DGBI相容的症状谱之间有很强的联系(例如，IBD和肠道DGBI)和非对应(例如，IBD和食管DGBI）解剖区域。大便失禁和乳糜泻之间的联系最强，或6.94[4.95,9.73]。在调整混杂因素后，协会减少，但坚持。
结论：与DGBI相容的症状谱在患有自我报告的器质性GI疾病和DM的个体中更常见。在有机（GI）疾病的管理中应考虑这些伴随的DGBIs的存在。
