Abstract：
Objective: To investigate the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea (FHA).
Methods: A retrospective cohort study was conducted to summarize the clinical and endocrine characteristics of 58 patients with FHA at initial diagnosis and to follow up the recovery of ovulation and spontaneous menstruation in the patients to investigate these biochemical indicators and their effects on recovery outcomes.
Results: Among patients with FHA, 13.8% (8/58) and 15.5% (9/58) had above moderately severe depressive and severe anxiety symptoms respectively, and 25.9% (15/58) were at high risk for eating disorders. 34.5% (20/58) were included assessed as having recovered. The non-recovered group had higher scores on the Patient Health Questionnaire (PHQ-9) (p = .022) and higher scores on the Eating Attitude Test-26 (EAT-26) (p = .03) as well as bulimia and food preoccupation (p = .041). Follicle diameter >5 mm at initial diagnosis was an independent factor influencing recovery of reproductive axis function (odds ratio = 7.532; 95% confidence interval, 1.321-42.930; p = .023).
Conculsions: Mood disorders and a certain risk of eating disorders were present in FHA.These, together with weight loss, endocrine and follicle size, could influence the outcome.
Methods: A retrospective cohort study was conducted to summarize the clinical and endocrine characteristics of 58 patients with FHA at initial diagnosis and to follow up the recovery of ovulation and spontaneous menstruation in the patients to investigate these biochemical indicators and their effects on recovery outcomes.
Results: Among patients with FHA, 13.8% (8/58) and 15.5% (9/58) had above moderately severe depressive and severe anxiety symptoms respectively, and 25.9% (15/58) were at high risk for eating disorders. 34.5% (20/58) were included assessed as having recovered. The non-recovered group had higher scores on the Patient Health Questionnaire (PHQ-9) (p = .022) and higher scores on the Eating Attitude Test-26 (EAT-26) (p = .03) as well as bulimia and food preoccupation (p = .041). Follicle diameter >5 mm at initial diagnosis was an independent factor influencing recovery of reproductive axis function (odds ratio = 7.532; 95% confidence interval, 1.321-42.930; p = .023).
Conculsions: Mood disorders and a certain risk of eating disorders were present in FHA.These, together with weight loss, endocrine and follicle size, could influence the outcome.
摘要：
目的:探讨饮食及情绪对功能性下丘脑性闭经(FHA)患者生殖轴功能的影响。
方法：采用回顾性队列研究方法，总结58例FHA患者初诊时的临床和内分泌特点，并随访患者的排卵和自发月经恢复情况，探讨这些生化指标及其对恢复结局的影响。
结果：FHA患者中，分别有13.8%(8/58)和15.5%(9/58)的中度以上抑郁和重度焦虑症状,25.9％（15/58）的饮食失调风险很高。包括34.5％（20/58）评估为已恢复。未恢复组的患者健康问卷（PHQ-9）得分较高（p=.022），饮食态度测试-26（EAT-26）得分较高（p=.03）以及贪食症和食物专注（p=.041）。初始诊断时卵泡直径>5mm是影响生殖轴功能恢复的独立因素(比值比=7.532;95%置信区间,1.321-42.930；p=0.023）。
结论：FHA存在情绪障碍和进食障碍的一定风险。这些,和减肥一起，内分泌和卵泡大小，可能会影响结果。
方法：采用回顾性队列研究方法，总结58例FHA患者初诊时的临床和内分泌特点，并随访患者的排卵和自发月经恢复情况，探讨这些生化指标及其对恢复结局的影响。
结果：FHA患者中，分别有13.8%(8/58)和15.5%(9/58)的中度以上抑郁和重度焦虑症状,25.9％（15/58）的饮食失调风险很高。包括34.5％（20/58）评估为已恢复。未恢复组的患者健康问卷（PHQ-9）得分较高（p=.022），饮食态度测试-26（EAT-26）得分较高（p=.03）以及贪食症和食物专注（p=.041）。初始诊断时卵泡直径>5mm是影响生殖轴功能恢复的独立因素(比值比=7.532;95%置信区间,1.321-42.930；p=0.023）。
结论：FHA存在情绪障碍和进食障碍的一定风险。这些,和减肥一起，内分泌和卵泡大小，可能会影响结果。
