Abstract：
Periodontitis is a cumulative inflammatory disease associated with multiple health conditions and various systemic diseases. As a common disease, virus infection along with its consequences has become a serious health burden. The study aims to evaluate the relationship between common viruses including hepatitis virus, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papillomavirus (HPV), and periodontitis. The data from the US National Health and Nutrition Examination Survey (NHANES) 2009-2014 was adopted and screened through, including 10 714 participants. Generalized linear regression was conducted to verify the relationships between the virus infections and periodontitis. Moreover, we also performed analyses in age and gender subgroups. The results suggested that the infection of HCV, HSV-1, and HSV-2 was significantly associated with the prevalence of periodontitis (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.26-1.70; OR 1.09, 95% CI 1.05-1.13; OR 1.06, 95% CI 1.01 - 1.11, respectively) and risk of developing moderate or severe periodontitis (OR 1.51, 95% CI 1.29-1.77; OR 1.08, 95% CI 1.04-1.12; OR 1.05, 95% CI 1.01-1.10, respectively) after adjusting all relevant co-factors. Subgroup analyses revealed a steady association between periodontitis and hepatitis C virus (HCV) or HSV-1 infection, while the relationship between HSV-2 and HPV infection can also be found in some subgroups. The presence of HCV and HSV infection was found to be significantly associated with the prevalence of periodontitis, including moderate or severe cases. Moreover, the association of periodontitis and HPV infection can also be observed in people < 35 years.
摘要：
牙周炎是与多种健康状况和各种全身性疾病相关的累积炎症性疾病。作为一种常见病,病毒感染及其后果已成为严重的健康负担。该研究旨在评估包括肝炎病毒在内的常见病毒之间的关系，人类免疫缺陷病毒（HIV），单纯疱疹病毒(HSV),人乳头瘤病毒（HPV），和牙周炎。2009-2014年美国国家健康和营养检查调查（NHANES）的数据被采用并筛选，包括10714人。进行广义线性回归以验证病毒感染与牙周炎之间的关系。此外，我们还对年龄和性别亚组进行了分析.结果提示HCV感染,HSV-1和HSV-2与牙周炎的患病率显着相关（比值比[OR]1.46，95％置信区间[CI]1.26-1.70；OR1.09，95％CI1.05-1.13；OR1.06，95％CI1.01-1.11）和发生中度或重度牙周炎的风险（OR1.51，95％CI1.29-1.77）；OR1.08-95％-1.12亚组分析显示牙周炎与丙型肝炎病毒（HCV）或HSV-1感染之间有稳定的关联，而HSV-2与HPV感染之间的关系也可以在一些亚组中发现。发现HCV和HSV感染的存在与牙周炎的患病率显着相关，包括中度或重度病例。此外，在<35岁的人群中也可以观察到牙周炎和HPV感染的关联。
