PDF(Pubmed)
Abstract：
UNASSIGNED: Hepatocellular carcinomas (HCC) have a high morbidity and mortality rate, and is difficult to cure and prone to recurrence when it has already developed. Therefore, early detection and efficient treatment of HCC is necessary.
UNASSIGNED: In this study, we synthesized a novel NDI polymer with uniform size, long-term stability, and high near-infrared two-zone (NIR-II) absorption efficiency, which can greatly enhance the effect of photothermal therapy (PTT) after intravenous injection into Huh-7-tumor bearing mice.
UNASSIGNED: The in vitro and in vivo studies showed that NDI polymer exhibited excellent NIR-guided PTT treatment, and the antitumor effect was approximately 88.5%, with obvious antimetastatic effects.
UNASSIGNED: This study developed an NDI polymer-mediated integrated diagnostic and therapeutic modality for NIR-II fluorescence imaging and photothermal therapy.
UNASSIGNED: In this study, we synthesized a novel NDI polymer with uniform size, long-term stability, and high near-infrared two-zone (NIR-II) absorption efficiency, which can greatly enhance the effect of photothermal therapy (PTT) after intravenous injection into Huh-7-tumor bearing mice.
UNASSIGNED: The in vitro and in vivo studies showed that NDI polymer exhibited excellent NIR-guided PTT treatment, and the antitumor effect was approximately 88.5%, with obvious antimetastatic effects.
UNASSIGNED: This study developed an NDI polymer-mediated integrated diagnostic and therapeutic modality for NIR-II fluorescence imaging and photothermal therapy.
摘要：
■肝细胞癌（HCC）具有很高的发病率和死亡率，并且难以治愈，并且在已经发展时容易复发。因此,肝癌的早期发现和有效治疗是必要的。
■在这项研究中，我们合成了一种尺寸均匀的新型NDI聚合物，长期稳定，和高近红外两区（NIR-II）吸收效率，对Huh-7荷瘤小鼠静脉注射后，可以大大提高光热治疗（PTT）的效果。
■体外和体内研究表明，NDI聚合物表现出优异的NIR引导PTT治疗，抗肿瘤效果约为88.5%，具有明显的抗转移作用。
■这项研究开发了NDI聚合物介导的综合诊断和治疗模式，用于NIR-II荧光成像和光热治疗。
■在这项研究中，我们合成了一种尺寸均匀的新型NDI聚合物，长期稳定，和高近红外两区（NIR-II）吸收效率，对Huh-7荷瘤小鼠静脉注射后，可以大大提高光热治疗（PTT）的效果。
■体外和体内研究表明，NDI聚合物表现出优异的NIR引导PTT治疗，抗肿瘤效果约为88.5%，具有明显的抗转移作用。
■这项研究开发了NDI聚合物介导的综合诊断和治疗模式，用于NIR-II荧光成像和光热治疗。
