UNASSIGNED: In this study, we synthesized a novel NDI polymer with uniform size, long-term stability, and high near-infrared two-zone (NIR-II) absorption efficiency, which can greatly enhance the effect of photothermal therapy (PTT) after intravenous injection into Huh-7-tumor bearing mice.
UNASSIGNED: The in vitro and in vivo studies showed that NDI polymer exhibited excellent NIR-guided PTT treatment, and the antitumor effect was approximately 88.5%, with obvious antimetastatic effects.
UNASSIGNED: This study developed an NDI polymer-mediated integrated diagnostic and therapeutic modality for NIR-II fluorescence imaging and photothermal therapy.
■在这项研究中,我们合成了一种尺寸均匀的新型NDI聚合物,长期稳定,和高近红外两区(NIR-II)吸收效率,对Huh-7荷瘤小鼠静脉注射后,可以大大提高光热治疗(PTT)的效果。
■体外和体内研究表明,NDI聚合物表现出优异的NIR引导PTT治疗,抗肿瘤效果约为88.5%,具有明显的抗转移作用。
■这项研究开发了NDI聚合物介导的综合诊断和治疗模式,用于NIR-II荧光成像和光热治疗。