%0 Journal Article
%T NIR-II-Absorbing NDI Polymer with Superior Penetration Depth for Enhanced Photothermal Therapy Efficiency of Hepatocellular Carcinoma.
%A Li B
%A Luo Y
%A Liu G
%A Gou M
%A Feng L
%A Ye X
%A Xu J
%A Fan Y
%A You Z
%J Int J Nanomedicine
%V 19
%N 0
%D 2024
%M 38975319
暂无%R 10.2147/IJN.S465631
%X <B>UNASSIGNED: </B>Hepatocellular carcinomas (HCC) have a high morbidity and mortality rate, and is difficult to cure and prone to recurrence when it has already developed. Therefore, early detection and efficient treatment of HCC is necessary.<BR><B>UNASSIGNED: </B>In this study, we synthesized a novel NDI polymer with uniform size, long-term stability, and high near-infrared two-zone (NIR-II) absorption efficiency, which can greatly enhance the effect of photothermal therapy (PTT) after intravenous injection into Huh-7-tumor bearing mice.<BR><B>UNASSIGNED: </B>The in vitro and in vivo studies showed that NDI polymer exhibited excellent NIR-guided PTT treatment, and the antitumor effect was approximately 88.5%, with obvious antimetastatic effects.<BR><B>UNASSIGNED: </B>This study developed an NDI polymer-mediated integrated diagnostic and therapeutic modality for NIR-II fluorescence imaging and photothermal therapy.