PDF(Pubmed)
Abstract：
UNASSIGNED: Extramammary Paget\'s disease (EMPD) is a rare skin cancer with unclear pathogenesis, insidious progression, and high recurrence rate. The purpose of this study was to investigate the clinical features and postoperative recurrence factors of primary EMPD.
UNASSIGNED: We retrospectively analyzed the medical records of 40 patients with primary EMPD who underwent wide local excision surgery at a single medical center between 2009 and 2019. Risk factors for recurrence of primary EMPD were analyzed using multivariate binary logistic regression.
UNASSIGNED: The study included 40 patients with primary EMPD, comprising 31 males (77.5%) and 9 females (22.5%), with a median age of 75.52 years (range 52-99 years). The most common lesion location was the scrotum (22 cases, 55.0%), followed by the vulva, penis, scrotum, underarm and anus. Multivariable regression analysis revealed significant differences in the presence of ill-defined tumour borders, exudation and nodules in the primary lesion affecting the relapse of primary EMPD (p<0.05).
UNASSIGNED: Our findings indicate that ill-defined tumour borders, exudation and nodules in the primary site should be considered as independent risk factors for disease recurrence, which may provide useful suggestions for the diagnosis, treatment and follow-up of primary EMPD.
UNASSIGNED: We retrospectively analyzed the medical records of 40 patients with primary EMPD who underwent wide local excision surgery at a single medical center between 2009 and 2019. Risk factors for recurrence of primary EMPD were analyzed using multivariate binary logistic regression.
UNASSIGNED: The study included 40 patients with primary EMPD, comprising 31 males (77.5%) and 9 females (22.5%), with a median age of 75.52 years (range 52-99 years). The most common lesion location was the scrotum (22 cases, 55.0%), followed by the vulva, penis, scrotum, underarm and anus. Multivariable regression analysis revealed significant differences in the presence of ill-defined tumour borders, exudation and nodules in the primary lesion affecting the relapse of primary EMPD (p<0.05).
UNASSIGNED: Our findings indicate that ill-defined tumour borders, exudation and nodules in the primary site should be considered as independent risk factors for disease recurrence, which may provide useful suggestions for the diagnosis, treatment and follow-up of primary EMPD.
摘要：
■乳腺外Paget病(EMPD)是一种罕见的皮肤癌,发病机制不明确,阴险的进展，和高复发率。目的探讨原发性EMPD的临床特点及术后复发因素。
■我们回顾性分析了2009年至2019年间在单个医疗中心接受广泛局部切除手术的40例原发性EMPD患者的病历。采用多元二元logistic回归分析原发性EMPD复发的危险因素。
■该研究包括40例原发性EMPD患者，包括31名男性(77.5%)和9名女性(22.5%)，年龄中位数为75.52岁（范围52-99岁）。最常见的病变部位是阴囊（22例，55.0%），接着是外阴，阴茎,阴囊,腋下和肛门。多变量回归分析显示肿瘤边界不明确的存在显着差异，原发性病变的渗出和结节影响原发性EMPD的复发（p<0.05）。
■我们的研究结果表明，肿瘤边界不明确，原发部位的渗出和结节应被视为疾病复发的独立危险因素，这可能为诊断提供有用的建议，原发性EMPD的治疗和随访。
■我们回顾性分析了2009年至2019年间在单个医疗中心接受广泛局部切除手术的40例原发性EMPD患者的病历。采用多元二元logistic回归分析原发性EMPD复发的危险因素。
■该研究包括40例原发性EMPD患者，包括31名男性(77.5%)和9名女性(22.5%)，年龄中位数为75.52岁（范围52-99岁）。最常见的病变部位是阴囊（22例，55.0%），接着是外阴，阴茎,阴囊,腋下和肛门。多变量回归分析显示肿瘤边界不明确的存在显着差异，原发性病变的渗出和结节影响原发性EMPD的复发（p<0.05）。
■我们的研究结果表明，肿瘤边界不明确，原发部位的渗出和结节应被视为疾病复发的独立危险因素，这可能为诊断提供有用的建议，原发性EMPD的治疗和随访。
