PDF(Pubmed)
Abstract：
UNASSIGNED: Due to the COVID-19 pandemic, many countries around the world experienced an unprecedented increase in stress in the general population. Even after normal life has been reestablished, the new normal is punctuated by severely impacted vulnerable groups. Stress-associated symptoms display an intricate relationship with biochemical modulations, which coordinate the stress response. Identifying these biochemical factors is inherent to deciphering the mode of treatment needed to diminish the health-care gap resulting from the pandemic.
UNASSIGNED: We applied psychological measures using the perceived stress (PS) and COVID-19 anxiety (CA) scales and preventive health behavior (PHB) to evaluate stress in the general population. Biochemical markers of stress, that is, total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), cortisol, and C-reactive protein (CRP) were tested in the serum samples of the participants. Statistical analysis was carried out using SPSS version 22.0.
UNASSIGNED: Stress scores for PS, CA, and PHB indicate the prevalence of moderate-to-high stress among participants, and a correlation between psychological stress and biochemical correlates, TAC, TBARS, cortisol, and CRP. Serum concentrations of TBARS, Cortisol, and CRP were found to be significantly increased, while the TAC was decreased across all stress types and levels. Our findings demonstrate a positive correlation between PS, CA, PHB TBARS, cortisol, and CRP and a strong negative correlation with TAC.
UNASSIGNED: The results of this study will help in tailoring targeted interventions and preventive regimes to mitigate COVID-19-associated anxiety and stress disorders prevailing even after the actual pandemic has subsided.
UNASSIGNED: We applied psychological measures using the perceived stress (PS) and COVID-19 anxiety (CA) scales and preventive health behavior (PHB) to evaluate stress in the general population. Biochemical markers of stress, that is, total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), cortisol, and C-reactive protein (CRP) were tested in the serum samples of the participants. Statistical analysis was carried out using SPSS version 22.0.
UNASSIGNED: Stress scores for PS, CA, and PHB indicate the prevalence of moderate-to-high stress among participants, and a correlation between psychological stress and biochemical correlates, TAC, TBARS, cortisol, and CRP. Serum concentrations of TBARS, Cortisol, and CRP were found to be significantly increased, while the TAC was decreased across all stress types and levels. Our findings demonstrate a positive correlation between PS, CA, PHB TBARS, cortisol, and CRP and a strong negative correlation with TAC.
UNASSIGNED: The results of this study will help in tailoring targeted interventions and preventive regimes to mitigate COVID-19-associated anxiety and stress disorders prevailing even after the actual pandemic has subsided.
摘要：
■由于COVID-19大流行，世界上许多国家的普通人口压力空前增加。即使在恢复正常生活之后，受到严重影响的弱势群体打断了新常态。与压力相关的症状与生化调节有着复杂的关系，协调应激反应。识别这些生化因素对于破译缩小大流行造成的医疗保健差距所需的治疗模式是固有的。
■我们使用感知压力（PS）和COVID-19焦虑（CA）量表和预防性健康行为（PHB）进行了心理测量，以评估普通人群的压力。应激的生化标记，也就是说,总抗氧化能力(TAC)，硫代巴比妥酸反应性物质（TBARS），皮质醇,在参与者的血清样本中检测C反应蛋白（CRP）。使用SPSS版本22.0进行统计学分析。
■PS的压力分数，CA,PHB表明参与者中高压力的患病率，以及心理压力和生化相关因素之间的相关性，TAC,TBARS,皮质醇,CRP。血清TBARS浓度,皮质醇,和CRP被发现显着增加，而TAC在所有应激类型和水平上都降低。我们的发现表明PS之间存在正相关，CA,PHBTBARS,皮质醇,CRP与TAC呈强负相关。
■这项研究的结果将有助于制定有针对性的干预措施和预防方案，以缓解与COVID-19相关的焦虑和应激障碍，即使在实际大流行消退后也是如此。
■我们使用感知压力（PS）和COVID-19焦虑（CA）量表和预防性健康行为（PHB）进行了心理测量，以评估普通人群的压力。应激的生化标记，也就是说,总抗氧化能力(TAC)，硫代巴比妥酸反应性物质（TBARS），皮质醇,在参与者的血清样本中检测C反应蛋白（CRP）。使用SPSS版本22.0进行统计学分析。
■PS的压力分数，CA,PHB表明参与者中高压力的患病率，以及心理压力和生化相关因素之间的相关性，TAC,TBARS,皮质醇,CRP。血清TBARS浓度,皮质醇,和CRP被发现显着增加，而TAC在所有应激类型和水平上都降低。我们的发现表明PS之间存在正相关，CA,PHBTBARS,皮质醇,CRP与TAC呈强负相关。
■这项研究的结果将有助于制定有针对性的干预措施和预防方案，以缓解与COVID-19相关的焦虑和应激障碍，即使在实际大流行消退后也是如此。
