UNASSIGNED: The Joanna Briggs Institute\'s updated 2020 methodological guidelines for conducting and guidance for scoping reviews were used. We meticulously adhered to the systemic review reporting items checklist and scoping review meta-analyses extension.
UNASSIGNED: Two hundred twenty-nine possibly relevant studies were searched. These include: 64, 54, 21, 48 and 42 from PubMed, Scopus, Google Scholar, EMBASE, and manual search, respectively. Seventy-seven duplicate studies were removed. Thirty-nine papers were rejected with justification, whereas 58 studies were qualified for full-text screening. Finally 19 studies were examined. The primary pharmacogene that was found to have a significant influence on the pharmacokinetics of efavirenz was CYP2B6. Drug-induced liver injury has frequently identified toxicity among studied medications.
UNASSIGNED: Pharmacogenomics studies in Ethiopian populations are less abundant. The studies conducted focused on infectious diseases, specifically on HAART commonly efavirenz and backbone first-line anti-tuberculosis drugs. There is a high need for further pharmacogenomics research to verify the discrepancies among the studies and for guiding precision medicine. Systematic review and meta-analysis are also recommended for pooled effects of different parameters in pharmacogenomics studies.
■使用了乔安娜·布里格斯研究所更新的2020年方法指南,用于进行范围审查和指导。我们一丝不苟地遵守系统审查报告项目清单和范围审查荟萃分析扩展。
■检索了二百二十九个可能相关的研究。其中包括:PubMed的64、54、21、48和42,Scopus,谷歌学者,EMBASE,和手动搜索,分别。删除了77项重复研究。三十九篇论文被拒绝,理由是合理的,而58项研究符合全文筛选条件.最后对19项研究进行了研究。发现对依非韦仑的药代动力学具有显着影响的主要药源是CYP2B6。药物诱导的肝损伤在所研究的药物中经常发现毒性。
■埃塞俄比亚人群的药物基因组学研究较少。进行的研究集中在传染病上,特别是对HAART通常是依非韦仑和骨干一线抗结核药物。迫切需要进一步的药物基因组学研究以验证研究之间的差异并指导精准医学。还建议对药物基因组学研究中不同参数的综合影响进行系统评价和荟萃分析。