PDF(Pubmed)
Abstract：
UNASSIGNED: Breast phyllodes tumors (BPT) have variable malignant potential, their histological classification remains insufficient for an accurate diagnosis.
UNASSIGNED: We attempted to investigate CD10 (Cluster of differentiation 10) and EGFR (Epidermal growth factor receptor) expression in BPT in order to highlight their diagnostic and prognostic values.
UNASSIGNED: Eight patients with BPT are recruited from January 2014 to December 2020 and immunohistochemical assessment of CD10 and EGFR is realized.
UNASSIGNED: Median age was 27±15.2, the mean tumor size was 9.63±10.21. Only malignant tumours showed expression for EGFR. Borderline and malignant tumors were CD10 positive. Patients overexpressing CD10 were postmenopausal with great tumor size, 25% of these were sarcomatous. Coexistence of CD10 and EGFR overexpression was found in 25% of cases and was associated with age (P=0.008), tumor size (P=0.030) and hitologic types (P=0.014). PC1 and PC2, were extracted, they accounted cumulatively for 94.7% of the variance of the data analysed, it suggests that patient\'s age and histological type of tumor have significant association with CD10 and EGFR expression in BPT.
UNASSIGNED: EGFR and CD10 overexpressed combined proteins in phyllode tumors constitute, with histopathological parameters, an important prognostic factor as well as a promising potential targets.
UNASSIGNED: We attempted to investigate CD10 (Cluster of differentiation 10) and EGFR (Epidermal growth factor receptor) expression in BPT in order to highlight their diagnostic and prognostic values.
UNASSIGNED: Eight patients with BPT are recruited from January 2014 to December 2020 and immunohistochemical assessment of CD10 and EGFR is realized.
UNASSIGNED: Median age was 27±15.2, the mean tumor size was 9.63±10.21. Only malignant tumours showed expression for EGFR. Borderline and malignant tumors were CD10 positive. Patients overexpressing CD10 were postmenopausal with great tumor size, 25% of these were sarcomatous. Coexistence of CD10 and EGFR overexpression was found in 25% of cases and was associated with age (P=0.008), tumor size (P=0.030) and hitologic types (P=0.014). PC1 and PC2, were extracted, they accounted cumulatively for 94.7% of the variance of the data analysed, it suggests that patient\'s age and histological type of tumor have significant association with CD10 and EGFR expression in BPT.
UNASSIGNED: EGFR and CD10 overexpressed combined proteins in phyllode tumors constitute, with histopathological parameters, an important prognostic factor as well as a promising potential targets.
摘要：
■乳腺叶状肿瘤（BPT）具有可变的恶性潜能，他们的组织学分类仍然不足以准确诊断。
■我们试图研究CD10（分化簇10）和EGFR（表皮生长因子受体）在BPT中的表达，以突出它们的诊断和预后价值。
■从2014年1月至2020年12月招募了8名BPT患者，并实现了CD10和EGFR的免疫组织化学评估。
■中位年龄为27±15.2，平均肿瘤大小为9.63±10.21。只有恶性肿瘤显示EGFR表达。交界性及恶性肿瘤CD10阳性。过表达CD10的患者绝经后肿瘤体积较大，其中25％是肉瘤。在25%的病例中发现CD10和EGFR过表达共存，并与年龄相关(P=0.008)。肿瘤大小（P=0.030）和病理类型（P=0.014）。提取PC1和PC2，它们累计占分析数据方差的94.7%，提示BPT患者的年龄和肿瘤的组织学类型与CD10和EGFR的表达有显著的相关性。
■叶状肿瘤中EGFR和CD10过表达的组合蛋白构成，组织病理学参数，一个重要的预后因素以及有希望的潜在目标。
■我们试图研究CD10（分化簇10）和EGFR（表皮生长因子受体）在BPT中的表达，以突出它们的诊断和预后价值。
■从2014年1月至2020年12月招募了8名BPT患者，并实现了CD10和EGFR的免疫组织化学评估。
■中位年龄为27±15.2，平均肿瘤大小为9.63±10.21。只有恶性肿瘤显示EGFR表达。交界性及恶性肿瘤CD10阳性。过表达CD10的患者绝经后肿瘤体积较大，其中25％是肉瘤。在25%的病例中发现CD10和EGFR过表达共存，并与年龄相关(P=0.008)。肿瘤大小（P=0.030）和病理类型（P=0.014）。提取PC1和PC2，它们累计占分析数据方差的94.7%，提示BPT患者的年龄和肿瘤的组织学类型与CD10和EGFR的表达有显著的相关性。
■叶状肿瘤中EGFR和CD10过表达的组合蛋白构成，组织病理学参数，一个重要的预后因素以及有希望的潜在目标。
