UNASSIGNED: We attempted to investigate CD10 (Cluster of differentiation 10) and EGFR (Epidermal growth factor receptor) expression in BPT in order to highlight their diagnostic and prognostic values.
UNASSIGNED: Eight patients with BPT are recruited from January 2014 to December 2020 and immunohistochemical assessment of CD10 and EGFR is realized.
UNASSIGNED: Median age was 27±15.2, the mean tumor size was 9.63±10.21. Only malignant tumours showed expression for EGFR. Borderline and malignant tumors were CD10 positive. Patients overexpressing CD10 were postmenopausal with great tumor size, 25% of these were sarcomatous. Coexistence of CD10 and EGFR overexpression was found in 25% of cases and was associated with age (P=0.008), tumor size (P=0.030) and hitologic types (P=0.014). PC1 and PC2, were extracted, they accounted cumulatively for 94.7% of the variance of the data analysed, it suggests that patient\'s age and histological type of tumor have significant association with CD10 and EGFR expression in BPT.
UNASSIGNED: EGFR and CD10 overexpressed combined proteins in phyllode tumors constitute, with histopathological parameters, an important prognostic factor as well as a promising potential targets.
■我们试图研究CD10(分化簇10)和EGFR(表皮生长因子受体)在BPT中的表达,以突出它们的诊断和预后价值。
■从2014年1月至2020年12月招募了8名BPT患者,并实现了CD10和EGFR的免疫组织化学评估。
■中位年龄为27±15.2,平均肿瘤大小为9.63±10.21。只有恶性肿瘤显示EGFR表达。交界性及恶性肿瘤CD10阳性。过表达CD10的患者绝经后肿瘤体积较大,其中25%是肉瘤。在25%的病例中发现CD10和EGFR过表达共存,并与年龄相关(P=0.008)。肿瘤大小(P=0.030)和病理类型(P=0.014)。提取PC1和PC2,它们累计占分析数据方差的94.7%,提示BPT患者的年龄和肿瘤的组织学类型与CD10和EGFR的表达有显著的相关性。
■叶状肿瘤中EGFR和CD10过表达的组合蛋白构成,组织病理学参数,一个重要的预后因素以及有希望的潜在目标。