UNASSIGNED: A total of 120 patients aged 60-75 years were randomly allocated to one of two groups. Remifentanil 0.3μg/kg was used for analgesia. Patients were administered remimazolam besylate 7 mg (R group) or etomidate 0.1 mg/kg combined with 1% propofol 0.5 mg/kg (EP group) for induction, supplemental repeated doses were given as needed. Some time metrics, vital signs, adverse events were evaluated. Patients\' Mini-cog score and recovery questionnaires were compared.
UNASSIGNED: Compared to the EP group, the induction time was slightly longer in the R group (1.50 VS 1.15 minutes) (P<0.05), the time spent in the post-anesthesia care unit (PACU) was shorter (15.17 VS 17.40 minutes) (P<0.05). Compare with EP group, SBP was lower in R group at T15 and T25 time point, but heart rate was higher in T2, T3, T5 (P< 0.05). The Mini-Cog score was higher after the procedure (2.83 VS 2.58) (P<0.05). The incidence of respiratory adverse events was higher in the EP group than R group (18.3% VS 5.0%, P < 0.05). The most common adverse event in R group was hiccups. The sedation satisfaction rate and degree of amnesia were higher in the R group (66.7% VS 11.7%) (P < 0.05), and the effect on patient\'s life within 24 hours was lower (12.0% VS 30.5%) (P < 0.05).
UNASSIGNED: The safety and efficacy of remimazolam besylate are not inferior to those of etomidate combined with propofol, rendering it a safe option for sedation during gastrointestinal endoscopy in ASA I-II elderly patients, but care should be taken to monitor the occurrence of hiccups.
■将120名年龄在60-75岁的患者随机分为两组。采用瑞芬太尼0.3μg/kg镇痛。患者分别给予苯磺酸瑞米唑仑7mg(R组)或依托咪酯0.1mg/kg联合1%丙泊酚0.5mg/kg(EP组)进行诱导,根据需要给予补充重复剂量。一些时间指标,生命体征,对不良事件进行了评估.比较患者的Mini-cog评分和康复问卷。
■与EP组相比,R组诱导时间稍长(1.50VS1.15分钟)(P<0.05),在麻醉后监护病房(PACU)中花费的时间较短(15.17VS17.40分钟)(P<0.05)。与EP组相比,在T15和T25时间点,R组SBP较低,T2、T3、T5时心率较高(P<0.05)。术后Mini-Cog评分较高(2.83VS2.58)(P<0.05)。EP组呼吸不良事件发生率高于R组(18.3%VS5.0%,P<0.05)。R组最常见的不良事件是打嗝。R组患者的镇静满意率和健忘症程度均较高(66.7%VS11.7%)(P<0.05),对患者24小时内生活的影响较低(12.0%VS30.5%)(P<0.05)。
■苯磺酸瑞马唑仑的安全性和有效性不亚于依托咪酯联合丙泊酚,使其成为ASAI-II老年患者在胃肠内窥镜检查期间镇静的安全选择,但是应该注意监控打嗝的发生。