PDF(Pubmed)
Abstract：
UNASSIGNED: The primary goal of this study is to evaluate the relationship between Body Mass Index (BMI) and muscle atrophy in individuals with rotator cuff tears.
UNASSIGNED: This study consists of patients with rotator cuff tears identified by MRI from two independent cohorts, the Rotator Cuff Outcomes Workgroup (ROW) and the Multicenter Orthopaedic Outcomes Network (MOON). Presence of atrophy (yes/no) and severity of atrophy (as an ordinal variable) were assessed on MRI by expert physicians. We used multivariable regression models to evaluate the relationship between BMI and muscle atrophy while adjusting for age and sex in each study, conducted sensitivity analyses for full-thickness tear and combined results using inverse variance-weighted meta-analysis.
UNASSIGNED: A total of 539 patients (MOON=395, ROW=144) from the combined cohorts had MRI data available on muscle atrophy. Among these patients, 246 (46%) had atrophy of at least one of the muscles of the rotator cuff and 282 (52%) had full-thickness tears. In meta-analysis across both cohorts, each 5 kg/m2 increase in BMI was associated with a 21% (aOR=1.21, 95% CI=1.02, 1.43) increased odds of having muscle atrophy among individuals with any tear size, and 36% (aOR=1.36, 95% CI=1.01-1.81) increased odds among individuals with full-thickness tear.
UNASSIGNED: Higher BMI was associated with significantly higher odds of muscle atrophy in patiens with rotator cuff tears. More study is needed to unders1tand why and how this relationship exists, as well as whether interventions to reduce BMI may help improve outcomes for these patients.
UNASSIGNED: III.
UNASSIGNED: This study consists of patients with rotator cuff tears identified by MRI from two independent cohorts, the Rotator Cuff Outcomes Workgroup (ROW) and the Multicenter Orthopaedic Outcomes Network (MOON). Presence of atrophy (yes/no) and severity of atrophy (as an ordinal variable) were assessed on MRI by expert physicians. We used multivariable regression models to evaluate the relationship between BMI and muscle atrophy while adjusting for age and sex in each study, conducted sensitivity analyses for full-thickness tear and combined results using inverse variance-weighted meta-analysis.
UNASSIGNED: A total of 539 patients (MOON=395, ROW=144) from the combined cohorts had MRI data available on muscle atrophy. Among these patients, 246 (46%) had atrophy of at least one of the muscles of the rotator cuff and 282 (52%) had full-thickness tears. In meta-analysis across both cohorts, each 5 kg/m2 increase in BMI was associated with a 21% (aOR=1.21, 95% CI=1.02, 1.43) increased odds of having muscle atrophy among individuals with any tear size, and 36% (aOR=1.36, 95% CI=1.01-1.81) increased odds among individuals with full-thickness tear.
UNASSIGNED: Higher BMI was associated with significantly higher odds of muscle atrophy in patiens with rotator cuff tears. More study is needed to unders1tand why and how this relationship exists, as well as whether interventions to reduce BMI may help improve outcomes for these patients.
UNASSIGNED: III.
摘要：
■这项研究的主要目标是评估肩袖撕裂患者的体重指数（BMI）与肌肉萎缩之间的关系。
■本研究由来自两个独立队列的MRI确定的肩袖撕裂患者组成，旋转袖带结果工作组(ROW)和多中心骨科结果网络(MOON)。由专家医师在MRI上评估萎缩的存在(是/否)和萎缩的严重程度(作为序数变量)。我们使用多变量回归模型来评估BMI与肌肉萎缩之间的关系，同时在每个研究中调整年龄和性别，使用逆方差加权荟萃分析对全厚度泪液和组合结果进行敏感性分析。
■来自合并队列的539名患者（MOON=395，ROW=144）有关于肌肉萎缩的MRI数据。在这些患者中,246（46％）的肩袖至少一块肌肉萎缩，282（52％）的撕裂厚度。在两个队列的荟萃分析中，BMI每增加5kg/m2与21%（aOR=1.21，95%CI=1.02，1.43）增加肌肉萎缩的可能性与任何泪液大小的个体，36％（aOR=1.36，95％CI=1.01-1.81）增加了全层泪液个体的几率。
■较高的BMI与肩袖撕裂患者肌肉萎缩的几率显著增高相关。需要更多的研究来了解这种关系的存在原因和方式，以及降低BMI的干预措施是否有助于改善这些患者的预后。
■III.
■本研究由来自两个独立队列的MRI确定的肩袖撕裂患者组成，旋转袖带结果工作组(ROW)和多中心骨科结果网络(MOON)。由专家医师在MRI上评估萎缩的存在(是/否)和萎缩的严重程度(作为序数变量)。我们使用多变量回归模型来评估BMI与肌肉萎缩之间的关系，同时在每个研究中调整年龄和性别，使用逆方差加权荟萃分析对全厚度泪液和组合结果进行敏感性分析。
■来自合并队列的539名患者（MOON=395，ROW=144）有关于肌肉萎缩的MRI数据。在这些患者中,246（46％）的肩袖至少一块肌肉萎缩，282（52％）的撕裂厚度。在两个队列的荟萃分析中，BMI每增加5kg/m2与21%（aOR=1.21，95%CI=1.02，1.43）增加肌肉萎缩的可能性与任何泪液大小的个体，36％（aOR=1.36，95％CI=1.01-1.81）增加了全层泪液个体的几率。
■较高的BMI与肩袖撕裂患者肌肉萎缩的几率显著增高相关。需要更多的研究来了解这种关系的存在原因和方式，以及降低BMI的干预措施是否有助于改善这些患者的预后。
■III.
