%0 Journal Article
%T Obesity is associated with muscle atrophy in rotator cuff tear.
%A Herzberg SD
%A Zhao Z
%A Freeman TH
%A Prakash R
%A Baumgarten KM
%A Bishop JY
%A Carey JL
%A Jones GL
%A McCarty EC
%A Spencer EE
%A Vidal AF
%A Jain NB
%A Giri A
%A Kuhn JE
%A Khazzam MS
%A Matzkin EG
%A Brophy RH
%A Dunn WR
%A Ma CB
%A Marx RG
%A Poddar SK
%A Smith MV
%A Wolf BR
%A Wright RW
%J BMJ Open Sport Exerc Med
%V 10
%N 2
%D 2024
%M 38974096
暂无%R 10.1136/bmjsem-2024-001993
%X <B>UNASSIGNED: </B>The primary goal of this study is to evaluate the relationship between Body Mass Index (BMI) and muscle atrophy in individuals with rotator cuff tears.<BR><B>UNASSIGNED: </B>This study consists of patients with rotator cuff tears identified by MRI from two independent cohorts, the Rotator Cuff Outcomes Workgroup (ROW) and the Multicenter Orthopaedic Outcomes Network (MOON). Presence of atrophy (yes/no) and severity of atrophy (as an ordinal variable) were assessed on MRI by expert physicians. We used multivariable regression models to evaluate the relationship between BMI and muscle atrophy while adjusting for age and sex in each study, conducted sensitivity analyses for full-thickness tear and combined results using inverse variance-weighted meta-analysis.<BR><B>UNASSIGNED: </B>A total of 539 patients (MOON=395, ROW=144) from the combined cohorts had MRI data available on muscle atrophy. Among these patients, 246 (46%) had atrophy of at least one of the muscles of the rotator cuff and 282 (52%) had full-thickness tears. In meta-analysis across both cohorts, each 5 kg/m2 increase in BMI was associated with a 21% (aOR=1.21, 95% CI=1.02, 1.43) increased odds of having muscle atrophy among individuals with any tear size, and 36% (aOR=1.36, 95% CI=1.01-1.81) increased odds among individuals with full-thickness tear.<BR><B>UNASSIGNED: </B>Higher BMI was associated with significantly higher odds of muscle atrophy in patiens with rotator cuff tears. More study is needed to unders1tand why and how this relationship exists, as well as whether interventions to reduce BMI may help improve outcomes for these patients.<BR><B>UNASSIGNED: </B>III.