PDF(Pubmed)
Abstract：
UNASSIGNED: Immune imbalance appears to have a critical role in tumor growth according to emerging research. Peripheral lymphocyte subsets are considered to reflect the systemic immune response and clinical prognosis. The prognostic value of lymphocyte subpopulations in myelodysplastic syndrome (MDS) patients remains unclear.
UNASSIGNED: A total of 94 MDS patients were enrolled for the study. X-tile software was performed to determine the prognostic significance of various lymphocyte subpopulations, CD3, CD4, CD8, CD4/CD8 ratio, natural killer cell (NK) and CD19. Among them, the appropriate threshold of NK percent could be found only. Patients were divided into the high NK percent group and the low NK percent group. The prognostic significance was determined by univariate and multivariate Cox hazard models.
UNASSIGNED: MDS patients with lower NK level had significantly shorter overall survival (OS). Based on univariate analysis, male gender (P = 0.030), lower HB (<10 g/dl, P = 0.029), higher BM blast (>5%, P < 0.0001), higher-risk IPSS-R cytogenetic (P = 0.032) and lower NK percent (P < 0.0001) were significantly associated with shorter OS. Multivariate Cox proportional hazards regression analysis indicated that low NK was also independent adverse prognostic factor for OS in MDS.
UNASSIGNED: Decreased NK level predicts poor prognosis independent of the IPSS-R and provide a novel evaluation factor for MDS patients.
UNASSIGNED: A total of 94 MDS patients were enrolled for the study. X-tile software was performed to determine the prognostic significance of various lymphocyte subpopulations, CD3, CD4, CD8, CD4/CD8 ratio, natural killer cell (NK) and CD19. Among them, the appropriate threshold of NK percent could be found only. Patients were divided into the high NK percent group and the low NK percent group. The prognostic significance was determined by univariate and multivariate Cox hazard models.
UNASSIGNED: MDS patients with lower NK level had significantly shorter overall survival (OS). Based on univariate analysis, male gender (P = 0.030), lower HB (<10 g/dl, P = 0.029), higher BM blast (>5%, P < 0.0001), higher-risk IPSS-R cytogenetic (P = 0.032) and lower NK percent (P < 0.0001) were significantly associated with shorter OS. Multivariate Cox proportional hazards regression analysis indicated that low NK was also independent adverse prognostic factor for OS in MDS.
UNASSIGNED: Decreased NK level predicts poor prognosis independent of the IPSS-R and provide a novel evaluation factor for MDS patients.
摘要：
■根据新兴研究，免疫失衡似乎在肿瘤生长中起关键作用。外周血淋巴细胞亚群被认为是反映全身免疫反应和临床预后的指标。淋巴细胞亚群在骨髓增生异常综合征（MDS）患者中的预后价值尚不清楚。
■本研究共纳入94例MDS患者。X-tile软件用于确定各种淋巴细胞亚群的预后意义，CD3，CD4，CD8，CD4/CD8比值，自然杀伤细胞（NK）和CD19。其中,NK百分比的适当阈值只能找到。将患者分为高NK百分比组和低NK百分比组。通过单变量和多变量Cox风险模型确定预后意义。
■NK水平较低的MDS患者的总生存期（OS）明显较短。基于单变量分析，男性（P=0.030），较低的HB（<10g/dl，P=0.029),较高的BM爆炸(>5%，P<0.0001),较高风险的IPSS-R细胞遗传学(P=0.032)和较低的NK百分比(P<0.0001)与较短的OS显著相关.多因素Cox比例风险回归分析显示，低NK也是MDS患者OS的独立不良预后因素。
■NK水平降低独立于IPSS-R预测不良预后，并为MDS患者提供新的评估因子。
■本研究共纳入94例MDS患者。X-tile软件用于确定各种淋巴细胞亚群的预后意义，CD3，CD4，CD8，CD4/CD8比值，自然杀伤细胞（NK）和CD19。其中,NK百分比的适当阈值只能找到。将患者分为高NK百分比组和低NK百分比组。通过单变量和多变量Cox风险模型确定预后意义。
■NK水平较低的MDS患者的总生存期（OS）明显较短。基于单变量分析，男性（P=0.030），较低的HB（<10g/dl，P=0.029),较高的BM爆炸(>5%，P<0.0001),较高风险的IPSS-R细胞遗传学(P=0.032)和较低的NK百分比(P<0.0001)与较短的OS显著相关.多因素Cox比例风险回归分析显示，低NK也是MDS患者OS的独立不良预后因素。
■NK水平降低独立于IPSS-R预测不良预后，并为MDS患者提供新的评估因子。
