PDF(Pubmed)
Abstract：
Intracranial volume (ICV) reflects maximal brain development and is associated with later-life cognitive abilities. We quantified ICV among first- and second-generation Hispanic and Latino adults from the Study of Latinos-Investigation of Cognitive Aging - MRI (SOL-INCA-MRI), estimated ICV heritability, and tested its associations with previously reported genetic variants, both individually and as a genetic risk score (GRS). We also estimated the association of ICV with early life environmental measures: nativity or age of immigration and parental education. The estimated heritability of ICV was 19% (95% CI, 0.1%-56%) in n=1781 unrelated SOL-INCA-MRI individuals. Four of 10 tested genetic variants were associated with ICV and an increase of 1 SD of the ICV-GRS was associated with an increase of 10.37 cm3 in the ICV (95% CI, 5.29-15.45). Compared to being born in the continental United States, immigrating to the United States at age 11 years or older was associated with 24 cm3 smaller ICV (95% CI, -39.97 to -8.06). Compared to both parents having less than high-school education, at least 1 parent completing high-school education was associated with 15.4 cm3 greater ICV (95% CI, 4.46-26.39). These data confirm the importance of early life health on brain development.
摘要：
颅内体积（ICV）反映了最大的大脑发育，并与以后的认知能力有关。我们从拉丁裔研究中量化了第一代和第二代西班牙裔和拉丁裔成年人的ICV-认知老化调查-MRI（SOL-INCA-MRI），估计ICV遗传力，并测试了其与先前报道的遗传变异的关联，无论是单独还是作为遗传风险评分(GRS)。我们还估计了ICV与早期生活环境措施的关联：出生或移民年龄和父母教育。在n=1781例无关的SOL-INCA-MRI个体中，ICV的估计遗传率为19％（95％CI，0.1％-56％）。10个测试的遗传变异中有4个与ICV相关，ICV-GRS增加1SD与ICV增加10.37cm3相关（95％CI，5.29-15.45）。与出生在美国大陆相比，11岁或以上移民美国的ICV较小24cm3(95%CI,-39.97~-8.06).与父母都没有受过高中教育相比，至少有1名父母完成高中教育后,ICV增加15.4cm3(95%CI,4.46~26.39).这些数据证实了早期生命健康对大脑发育的重要性。
