Abstract：
Currently, associations between dietary intakes of individual monounsaturated fatty acids (MUFAs) and hypertension were not well disclosed, and the interaction effects of MUFAs on their associations with hypertension were unknown. Obesity was correlated with both MUFAs and hypertension, while if anthropometric obesity indices performed mediating roles in associations between MUFAs and hypertension remained underdetermined. In our study, 8509 Chinese adults investigated from 2004 to 2011 were included. Dietary information collection and physical examinations were performed at baseline and each timepoint of follow-up. As we found, inverse associations of MUFA17, MUFA18 and MUFA20 with hypertension were statistically significant after adjustments, hazard ratios (HRs) were 0.87, 0.90 and 0.91, respectively. MUFA15 was positively associated with hypertension, with an HR of 1.07 (95% confidence interval: 1.01, 1.12). By performing principal component analysis (PCA) to estimate the joint effects of MUFAs on hypertension, the PCA score of MUFAs was only inversely associated with blood pressure. No joint effect was observed in g-computation analyses. Both linear and nonlinear interactions of MUFAs on their associations with hypertension were estimated using restricted cubic spline analysis. The association between MUFA15 and hypertension was interacted by MUFA17, and the association between MUFA20 and hypertension was interacted by MUFA18. The mediation effects of body mass index and waist circumference were found on associations of hypertension with MUFA15, MUFA17 and MUFA20. Our findings suggested that associations with hypertension were different among individual MUFAs, and mutual interactions existed, implying that the utility of individual MUFAs might be recommended for estimating relationships between MUFAs and diseases. Moreover, fat accumulation might potentially underlie associations between MUFAs and hypertension.
摘要：
目前,个体单不饱和脂肪酸（MUFA）的膳食摄入量与高血压之间的关联尚未得到充分披露，MUFA对其与高血压的关系的交互作用尚不清楚。肥胖与MUFA和高血压相关，而人体测量肥胖指数是否在MUFAs和高血压之间的关联中起中介作用仍然不确定。在我们的研究中,包括2004年至2011年调查的8509名中国成年人。在基线和随访的每个时间点进行饮食信息收集和体格检查。正如我们发现的,调整后MUFA17、MUFA18和MUFA20与高血压的负相关有统计学意义，风险比(HR)分别为0.87,0.90和0.91.MUFA15与高血压呈正相关，HR为1.07（95%置信区间：1.01，1.12）。通过主成分分析(PCA)来估计MUFA对高血压的联合作用,MUFA的PCA评分仅与血压呈负相关.在g计算分析中未观察到联合效应。使用有限的三次样条分析估计了MUFA与高血压关联的线性和非线性相互作用。MUFA17作用于MUFA15与高血压的关联,MUFA18作用于MUFA20与高血压的关联。发现体重指数和腰围对高血压与MUFA15，MUFA17和MUFA20的关联具有中介作用。我们的发现表明，与高血压的关联在各个MUFA之间是不同的，相互互动存在，这意味着可能建议使用单个MUFA来估计MUFA与疾病之间的关系。此外，脂肪积累可能是MUFA与高血压之间关联的潜在基础.
