Abstract：
Alloparenting refers to the practice of caring for the young by individuals other than their biological parents. The relationship between the dynamic changes in psychological functions underlying alloparenting and the development of specific neuroreceptors remains unclear. Using a classic 10-day pup sensitization procedure, together with a pup preference and pup retrieval test on the EPM (elevated plus maze), we showed that both male and female adolescent rats (24 days old) had significantly shorter latency than adult rats (65 days old) to be alloparental, and their motivation levels for pups and objects were also significantly higher. In contrast, adult rats retrieved more pups than adolescent rats even though they appeared to be more anxious on the EPM. Analysis of mRNA expression using real-time-PCR revealed a higher dopamine D2 receptor (DRD2) receptor expression in adult hippocampus, amygdala, and ventral striatum, along with higher dopamine D1 receptor (DRD1) receptor expression in ventral striatum compared to adolescent rats. Adult rats also showed significantly higher levels of 5-hydroxytryptamine receptor 2A (HTR2A) receptor expression in the medial prefrontal cortex, amygdala, ventral striatum, and hypothalamus. These results suggest that the faster onset of alloparenting in adolescent rats compared to adult rats, along with the psychological functions involved, may be mediated by varying levels of dopamine DRD1, DRD2, and HTR2A in different forebrain regions.
摘要：
同父异母是指由亲生父母以外的个人照顾年轻人的做法。同种异体父母的心理功能的动态变化与特定神经受体的发育之间的关系尚不清楚。使用经典的10天幼犬致敏程序，在EPM（高架迷宫）上进行幼犬偏好和幼犬检索测试，我们发现，雄性和雌性青春期大鼠（24日龄）的潜伏期明显短于成年大鼠（65日龄），他们对幼崽和物体的动机水平也明显更高。相比之下,成年大鼠比青春期大鼠获得更多的幼崽，尽管它们在EPM上似乎更焦虑。使用real-time-PCR对mRNA表达的分析显示，成人海马中多巴胺D2受体（DRD2）受体表达更高，杏仁核,和腹侧纹状体，与青春期大鼠相比，腹侧纹状体的多巴胺D1受体（DRD1）受体表达更高。成年大鼠在内侧前额叶皮质中5-羟色胺受体2A(HTR2A)受体表达水平也显著升高,杏仁核,腹侧纹状体,还有下丘脑.这些结果表明，与成年大鼠相比，青春期大鼠的同种异体开始更快，以及所涉及的心理功能，可能是由不同前脑区域的多巴胺DRD1，DRD2和HTR2A水平变化介导的。
