Abstract：
Functional recovery after peripheral nerve injuries is disappointing despite surgical advances in nerve repair. This review summarizes the relatively short window of opportunity for successful nerve regeneration due to the decline in the expression of growth-associated genes and in turn, the decline in regenerative capacity of the injured neurons and the support provided by the denervated Schwann cells, and the atrophy of denervated muscles. Brief, low-frequency electrical stimulation and post-injury exercise regimes ameliorate these deficits in animal models and patients, but the misdirection of regenerating nerve fibers compromises functional recovery and remains an important area of future research.
摘要：
尽管神经修复的手术取得了进展，但周围神经损伤后的功能恢复令人失望。这篇综述总结了由于生长相关基因的表达下降而导致的相对较短的神经再生机会，受损神经元再生能力的下降和去神经施万细胞提供的支持，和神经支配的肌肉萎缩。Brief,低频电刺激和损伤后运动方案改善了动物模型和患者的这些缺陷，但是再生神经纤维的误导影响了功能恢复，仍然是未来研究的重要领域。
