METHODS: In total, 116 patients, aged 65 years or older, were included in this cross-sectional study. If three or more signs or symptoms in seven kinds of tests met the criteria of each test, oral hypofunction was diagnosed. The levels of biomarkers in the saliva collected from the patients were analyzed using an enzyme-linked immunosorbent assay.
RESULTS: In total, 63.8% of patients were diagnosed with oral hypofunction. Multivariable linear regression analysis showed that calprotectin levels in the saliva were significantly related to oral moisture and masticatory function. Furthermore, 8-OHdG levels in saliva were associated with the movement function of the tongue and lips and oral hygiene level, and salivary AGE correlated only with the movement function of the tongue and lips. Multiple logistic regression analysis revealed that calprotectin levels in the saliva were significantly correlated with the prevalence of oral hypofunction, even after adjusting for age, sex, and periodontal status. However, none of the biomarker levels in the saliva had a significant relationship with the number of examinations outside the reference range.
CONCLUSIONS: Calprotectin, 8-OHdG, and AGE levels are associated with oral hypofunction in older adults.
方法:总共,116名患者,65岁或以上,纳入本横断面研究。如果七种测试中的三个或更多体征或症状符合每种测试的标准,诊断为口腔功能减退。使用酶联免疫吸附测定法分析从患者收集的唾液中的生物标志物水平。
结果:总计,63.8%的患者被诊断为口腔功能减退。多元线性回归分析显示,唾液中钙卫蛋白水平与口腔水分和咀嚼功能显著相关。此外,唾液中8-OHdG水平与舌头和嘴唇的运动功能和口腔卫生水平有关,唾液AGE仅与舌头和嘴唇的运动功能相关。多因素logistic回归分析显示唾液中钙卫蛋白水平与口腔功能减退的患病率显著相关,即使在调整了年龄之后,性别,和牙周状况。然而,唾液中的生物标志物水平与参考范围以外的检查次数无显著关系.
结论:钙卫蛋白,8-OHdG,和年龄水平与老年人口腔功能减退有关。