Abstract：
Cancer is a pernicious and pressing medical problem; moreover, it is a failure of multicellular morphogenesis that sheds much light on evolutionary developmental biology. Numerous classes of pharmacological agents have been considered as cancer therapeutics and evaluated as potential carcinogenic agents; however, these are spread throughout the primary literature. Here, we briefly review recent work on ion channel drugs as promising anti-cancer treatments and present a systematic review of the known cancer-relevant effects of 109 drugs targeting ion channels. The roles of ion channels in cancer are consistent with the importance of bioelectrical parameters in cell regulation and with the functions of bioelectric signaling in morphogenetic signals that act as cancer suppressors. We find that compounds that are well-known for having targets in the nervous system, such as voltage-gated ion channels, ligand-gated ion channels, proton pumps, and gap junctions are especially relevant to cancer. Our review suggests further opportunities for the repurposing of numerous promising candidates in the field of cancer electroceuticals.
摘要：
癌症是一个有害而紧迫的医学问题；此外，多细胞形态发生的失败揭示了进化发育生物学。许多种类的药物已被认为是癌症治疗剂，并被评估为潜在的致癌剂；然而，这些都传遍了主要文献。这里,我们简要回顾了离子通道药物作为有希望的抗癌治疗方法的最新研究，并对109种靶向离子通道的药物的已知癌症相关作用进行了系统综述。离子通道在癌症中的作用与生物电参数在细胞调节中的重要性以及在充当癌症抑制剂的形态发生信号中的生物电信号传导的功能一致。我们发现众所周知的在神经系统中具有靶标的化合物，如电压门控离子通道，配体门控离子通道，质子泵,缝隙连接与癌症尤其相关。我们的评论提出了在癌症药物领域重新利用许多有前途的候选人的进一步机会。
