Abstract：
The skin, which covers an area of 2 square meters of an adult human, accounts for about 15 % of the total body weight and is the body\'s largest organ. It protects internal organs from external physical, chemical, and biological attacks, prevents excess water loss from the body, and plays a role in thermoregulation. The skin is constantly exposed to various damages so that wounds can be acute or chronic. Although wound healing includes hemostasis, inflammatory, proliferation, and remodeling, chronic wounds face different treatment problems due to the prolonged inflammatory phase. Herbal extracts such as Nigella Sativa, curcumin, chamomile, neem, nettle, etc., with varying properties, including antibacterial, antioxidant, anti-inflammatory, antifungal, and anticancer, are used for wound healing. Due to their instability, herbal extracts are loaded in wound dressings to facilitate skin wounds. To promote skin wounds, skin tissue engineering was developed using polymers, bioactive molecules, and biomaterials in wound dressing. Conventional wound dressings, such as bandages, gauzes, and films, can\'t efficiently respond to wound healing. Adhesion to the wounds can worsen the wound conditions, increase inflammation, and cause pain while removing the scars. Ideal wound dressings have good biocompatibility, moisture retention, appropriate mechanical properties, and non-adherent and proper exudate management. Therefore, by electrospinning for wound healing applications, natural and synthesis polymers are utilized to fabricate nanofibers with high porosity, high surface area, and suitable mechanical and physical properties. This review explains the application of different herbal extracts with different chemical structures in nanofibrous webs used for wound care.
摘要：
皮肤，占地2平方米的成年人，约占全身重量的15%，是人体最大的器官。它保护内脏器官免受外部物理伤害，化学,和生物攻击，防止体内多余的水分流失，并在体温调节中起作用。皮肤经常暴露于各种损伤,使得伤口可以是急性的或慢性的。虽然伤口愈合包括止血，炎症，扩散,和重塑，由于炎症期延长，慢性伤口面临不同的治疗问题。草药提取物，如NigellaSativa，姜黄素,洋甘菊,neem,荨麻,等。,具有不同的属性，包括抗菌，抗氧化剂，抗炎,抗真菌药,和抗癌，用于伤口愈合。由于不稳定,草药提取物被装载在伤口敷料中以促进皮肤伤口。为了促进皮肤伤口，皮肤组织工程是使用聚合物开发的，生物活性分子，和伤口敷料中的生物材料。常规伤口敷料,比如绷带，纱布,和电影,不能有效地响应伤口愈合。对伤口的粘附会使伤口状况恶化，增加炎症，并在去除疤痕时引起疼痛。理想的伤口敷料具有良好的生物相容性，保湿,适当的机械性能，以及非粘附性和适当的渗出物管理。因此,通过静电纺丝用于伤口愈合应用，天然和合成聚合物用于制造高孔隙率的纳米纤维，高表面积,和合适的机械和物理性能。这篇综述解释了具有不同化学结构的不同草药提取物在用于伤口护理的纳米纤维网中的应用。
