Abstract：
Neurodegenerative diseases have multifactorial pathogenesis, mainly involving neuroinflammatory processes. Finding drugs able to treat these diseases, expecially because for most of these diseases there are no effective drugs, and the current drugs cause undesired side effects, represent a crucial point. Most in vivo and in vitro studies have been concentrated on various aspects related to neurons (e.g. neuroprotection), however, there has not been focus on the prevention of early stages involving glial cell activation and neuroinflammation. Recently, it has been demonstrated that nutritional phytochemicals including polyphenols, the main active constituents of the Mediterranean diet, maintain redox balance and neuroprotection through the activation of hormetic vitagene pathway. Recent lipidomics data from our laboratory indicate mushrooms as strong nutritional neuronutrients with strongly activity against neuroinflammation in Meniere\' diseaseas, a model of cochleovestibular neural degeneration, as well as in animal model of traumatic brain injury, or rotenone induced parkinson\'s disease. Moreover, Hidrox®, an aqueous extract of olive containing hydroxytyrosol, and Boswellia, acting as Nrf2 activators, promote resilience by enhancing the redox potential, and thus, regulate through hormetic mechanisms, cellular stress response mechanisms., Thus, modulation of cellular stress pathways, in particular vitagenes system, may be an innovative approach for therapeutic intervention in neurodegenerative disorders.
摘要：
神经退行性疾病具有多因素的发病机制，主要涉及神经炎症过程。寻找能够治疗这些疾病的药物，尤其是因为对于大多数这些疾病，没有有效的药物，目前的药物会引起不良的副作用，代表了一个关键点。大多数体内和体外研究都集中在与神经元相关的各个方面（例如神经保护）。然而,尚未将重点放在预防涉及神经胶质细胞活化和神经炎症的早期阶段。最近,已经证明，包括多酚在内的营养植物化学物质，地中海饮食的主要活性成分，通过激活维生素途径维持氧化还原平衡和神经保护。来自我们实验室的最新脂质组学数据表明，蘑菇是强大的营养神经营养素，在梅尼埃病中具有强烈的对抗神经炎症的活性，耳蜗前庭神经变性的模型，以及创伤性脑损伤的动物模型，或鱼藤酮诱发帕金森病。此外，Hidrox®,含有羟基酪醇的橄榄水提取物，和Boswellia,作为Nrf2活化剂，通过增强氧化还原电位来促进恢复力，因此，通过封闭机制进行调节，细胞应激反应机制。,因此，细胞应激途径的调节，特别是vitagenes系统，可能是神经退行性疾病治疗干预的创新方法。
