Abstract：
BACKGROUND: Shift work is associated with susceptibility to several neuropsychiatric disorders. This study aims to investigate the effect of shift work on the incidence of neuropsychiatric disorders, and highlighting how individual variability may influence the association.
METHODS: UK Biobank participants with employment information were included. Cox survival was conducted in main and subgroup analyses. Correlation analyses explored the impact of shift work on brain structures, and mediation analyses were performed to elucidate the shared underlying mechanisms. Shift work tolerance was evaluated through survival analyses contrasting the risks associated with five neuropsychiatric disorders in shift versus non-shift workers across different demographic or occupational strata.
RESULTS: The analysis encompassed 254,646 participants. Shift work was associated with higher risk of dementia (HR 1.29, 95 % CI 1.10-1.52), anxiety (1.08, 1.01-1.15), depression (1.29, 1.22-1.36), and sleep disorders (1.18, 1.09-1.28), but not stroke (p = 0.20). Shift work was correlated with decreasing volume of various brain regions, particularly in thalamus, lateral orbitofrontal, and middle temporal. Mediation analysis revealed that increased immune response and glucose levels are common pathways linking shift work to these disorders. We observed diversity in shift work tolerance across different individual characteristics, among which socioeconomic status and length of working hours were the most essential.
CONCLUSIONS: Self-reported employment information may cause misclassification and recall bias. And since we focused on the middle-aged population, the conclusions may not be representative of younger or older populations.
CONCLUSIONS: Our findings indicated the need to monitor shift worker health and provide personalized management to help adapt to shift work.
METHODS: UK Biobank participants with employment information were included. Cox survival was conducted in main and subgroup analyses. Correlation analyses explored the impact of shift work on brain structures, and mediation analyses were performed to elucidate the shared underlying mechanisms. Shift work tolerance was evaluated through survival analyses contrasting the risks associated with five neuropsychiatric disorders in shift versus non-shift workers across different demographic or occupational strata.
RESULTS: The analysis encompassed 254,646 participants. Shift work was associated with higher risk of dementia (HR 1.29, 95 % CI 1.10-1.52), anxiety (1.08, 1.01-1.15), depression (1.29, 1.22-1.36), and sleep disorders (1.18, 1.09-1.28), but not stroke (p = 0.20). Shift work was correlated with decreasing volume of various brain regions, particularly in thalamus, lateral orbitofrontal, and middle temporal. Mediation analysis revealed that increased immune response and glucose levels are common pathways linking shift work to these disorders. We observed diversity in shift work tolerance across different individual characteristics, among which socioeconomic status and length of working hours were the most essential.
CONCLUSIONS: Self-reported employment information may cause misclassification and recall bias. And since we focused on the middle-aged population, the conclusions may not be representative of younger or older populations.
CONCLUSIONS: Our findings indicated the need to monitor shift worker health and provide personalized management to help adapt to shift work.
摘要：
背景：轮班工作与几种神经精神疾病的易感性有关。这项研究旨在调查轮班工作对神经精神疾病发病率的影响，并强调个体差异如何影响这种关联。
方法：包含有就业信息的英国生物银行参与者。在主要和亚组分析中进行了Cox生存。相关分析探讨了轮班工作对大脑结构的影响，并进行了调解分析，以阐明共享的潜在机制。通过生存分析评估了轮班工作耐受力，对比了不同人口或职业阶层的轮班工作与非轮班工作者与五种神经精神疾病相关的风险。
结果：分析包括254,646名参与者。轮班工作与较高的痴呆风险相关(HR1.29,95%CI1.10-1.52),焦虑（1.08，1.01-1.15），抑郁症（1.29，1.22-1.36），和睡眠障碍（1.18，1.09-1.28），但不是中风（p=0.20）。轮班工作与大脑各个区域的体积减少有关，特别是在丘脑，外侧眶额，和中部时间。中介分析显示，免疫反应和葡萄糖水平的增加是将转移工作与这些疾病联系起来的常见途径。我们观察到不同个体特征的轮班工作容忍度差异，其中社会经济地位和工作时间是最重要的。
结论：自我报告的就业信息可能会导致错误分类和回忆偏差。因为我们关注的是中年人，结论可能不能代表年轻或老年人群.
结论：我们的研究结果表明，需要监测轮班工人的健康状况，并提供个性化管理，以帮助适应轮班工作。
方法：包含有就业信息的英国生物银行参与者。在主要和亚组分析中进行了Cox生存。相关分析探讨了轮班工作对大脑结构的影响，并进行了调解分析，以阐明共享的潜在机制。通过生存分析评估了轮班工作耐受力，对比了不同人口或职业阶层的轮班工作与非轮班工作者与五种神经精神疾病相关的风险。
结果：分析包括254,646名参与者。轮班工作与较高的痴呆风险相关(HR1.29,95%CI1.10-1.52),焦虑（1.08，1.01-1.15），抑郁症（1.29，1.22-1.36），和睡眠障碍（1.18，1.09-1.28），但不是中风（p=0.20）。轮班工作与大脑各个区域的体积减少有关，特别是在丘脑，外侧眶额，和中部时间。中介分析显示，免疫反应和葡萄糖水平的增加是将转移工作与这些疾病联系起来的常见途径。我们观察到不同个体特征的轮班工作容忍度差异，其中社会经济地位和工作时间是最重要的。
结论：自我报告的就业信息可能会导致错误分类和回忆偏差。因为我们关注的是中年人，结论可能不能代表年轻或老年人群.
结论：我们的研究结果表明，需要监测轮班工人的健康状况，并提供个性化管理，以帮助适应轮班工作。
