Abstract：
Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely expressed throughout the limbic system. Recent evidence has highlighted NPY as a marker of resilience to posttraumatic psychopathology, which may be due to its association with neural regions involved with emotion regulation. This study examined whether plasma NPY levels moderated the relationship between emotion regulation and psychopathology in a sample of adult survivors of childhood interpersonal trauma, a population known to be at high risk for psychopathology. Adults exposed to an interpersonal criterion A trauma during childhood (N = 54) were recruited from an urban population at a midwestern medical center and completed a baseline study visit as part of a larger clinical trial. Participants gave a blood sample in order to assess circulating levels of NPY and answered questions related to emotion regulation and mood-related pathology. Results of a moderated multiple regression showed that the overall model was significant R2 = 0.26, F (5, 48) = 3.46, p < .01. Difficulties in emotion regulation was significantly predictive of psychopathology (unstandardized B = 0.032, p < .01), and this relationship was significantly moderated by levels of NPY (unstandardized B = -0.001, p < .05) such that the relationship between emotion regulation and psychopathology was weaker for those with higher levels of NPY. Results suggest that higher levels of NPY may lessen the association between emotion regulation and posttraumatic psychopathology in survivors of childhood interpersonal trauma. Further investigation of the contribution of NPY to psychopathology in this population is warranted. NCT: 02279290.
摘要：
神经肽Y（NPY）是一种36个氨基酸的肽，在整个边缘系统中广泛表达。最近的证据强调NPY是创伤后精神病理学恢复力的标志，这可能是由于它与涉及情绪调节的神经区域有关。这项研究检查了在儿童期人际关系创伤的成年幸存者样本中，血浆NPY水平是否调节了情绪调节与精神病理学之间的关系，已知有精神病理学高风险的人群。暴露于人际关系标准的成年人在中西部医疗中心从城市人口中招募了童年时期的创伤（N=54），并作为较大临床试验的一部分完成了基线研究访问。参与者提供血液样本以评估NPY的循环水平，并回答与情绪调节和情绪相关病理有关的问题。多元回归结果显示,总体模型显著R2=0.26,F(5,48)=3.46,p<.01。情绪调节的困难是精神病理学的显著预测(未标准化的B=0.032,p<0.01),NPY水平显著调节了这种关系（未标准化的B=-0.001，p<.05），因此NPY水平较高的人的情绪调节和精神病理学之间的关系较弱。结果表明，较高的NPY水平可能会降低儿童期人际关系创伤幸存者的情绪调节与创伤后精神病理学之间的联系。有必要进一步研究NPY对该人群精神病理学的贡献。NCT:02279290。
