PDF(Pubmed)
Abstract：
Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.
摘要：
背景：褪黑激素是松果体产生的一种激素，具有抗氧化特性。
目的：本研究旨在通过系统评价和荟萃分析评估褪黑素对辅助生殖技术的影响。
方法：在过去15年中，PubMed和其他数据库中使用了搜索策略。经过资格筛选，选取17篇文章进行系统评价。对于荟萃分析统计，组成了两个小组，治疗组（使用褪黑素）和对照组（不使用褪黑素）的各种辅助生殖结局。
结果：主要结果是临床妊娠结局无统计学差异（p=0.64）。但对于成熟卵母细胞（MII）有统计学差异（p=0.001），窦卵泡计数（p=0.0002），和受精率(p≤0.0001)。
结论：褪黑素具有改善受精率等有益作用，尽管作者没有获得临床妊娠率的意义。
目的：本研究旨在通过系统评价和荟萃分析评估褪黑素对辅助生殖技术的影响。
方法：在过去15年中，PubMed和其他数据库中使用了搜索策略。经过资格筛选，选取17篇文章进行系统评价。对于荟萃分析统计，组成了两个小组，治疗组（使用褪黑素）和对照组（不使用褪黑素）的各种辅助生殖结局。
结果：主要结果是临床妊娠结局无统计学差异（p=0.64）。但对于成熟卵母细胞（MII）有统计学差异（p=0.001），窦卵泡计数（p=0.0002），和受精率(p≤0.0001)。
结论：褪黑素具有改善受精率等有益作用，尽管作者没有获得临床妊娠率的意义。
