%0 Journal Article
%T Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis.
%A Veiga ECA
%A Samama M
%A Ikeda F
%A Cavalcanti GS
%A Sartor A
%A Parames SF
%A Baracat EC
%A Ueno J
%A Junior JMS
%J Clinics (Sao Paulo)
%V 79
%N 0
%D 2024 Jul 5
%M 38971124
%F 2.898
%R 10.1016/j.clinsp.2024.100397
%X Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.<BR>This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.<BR>Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.<BR>The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).<BR>Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.