METHODS: Five cases of adult HNRMS (≥19 years) were retrieved from the archives of the Department of Pathology of Hospital of Specialities in Rabat (HSR) in Morocco, over 5 years. Clinical and pathologic findings from hematoxylin and eosin slides and immunohistochemistry for Desmin and Myogenin were reviewed.
UNASSIGNED: The median age was 33, with a men\'s predominance (3 M/2F). Histological analysis revealed three cases of Alveolar Rhabdomyosarcoma (RMS), one Pleomorphic RMS, and one spindle cell/sclerosing RMS. In addition to the typical histology observed in each RMS, we found tricky growth patterns that could be a source of misdiagnosis. All five cases demonstrated variable positivity for Desmin and Myogenin.
CONCLUSIONS: HNRMS cases have different pathological features than pediatric RMS cases. We identified rare subtypes such as pleomorphic and spindle cell/sclerotic RMS, which exhibit unusual morphological patterns.
方法:从摩洛哥拉巴特专科医院病理科(HSR)的档案中检索了5例成人HNRMS(≥19岁),超过5年。对苏木精和伊红载玻片的临床和病理发现以及Desmin和Myogenin的免疫组织化学进行了综述。
■中位年龄为33岁,以男性为主(3米/2华氏度)。组织学分析显示3例肺泡横纹肌肉瘤(RMS),一个多态RMS,和一个梭形细胞/硬化RMS。除了在每个RMS中观察到的典型组织学之外,我们发现了棘手的生长模式,这可能是误诊的原因。所有5例病例均显示Desmin和Myogenin的可变阳性。
结论:HNRMS病例与小儿RMS病例具有不同的病理特征。我们确定了罕见的亚型,如多形性和梭形细胞/硬化RMS,表现出不寻常的形态模式。