{Reference Type}: Journal Article
{Title}: Pathologic features of head and neck adult rhabdomyosarcoma: Case series.
{Author}: Ouazzani HE;Kadiri H;Habimana A;Boulaadas M;Zouaidia F;Cherradi N;
{Journal}: Int J Surg Case Rep
{Volume}: 121
{Issue}: 0
{Year}: 2024 Aug 3
暂无{DOI}: 10.1016/j.ijscr.2024.110001
{Abstract}: <B>BACKGROUND: </B>Adult Head and neck Rhabdomyosarcomas (HNRMS) are exceedingly rare and remain challenging for pathologists.<BR><B>METHODS: </B>Five cases of adult HNRMS (≥19 years) were retrieved from the archives of the Department of Pathology of Hospital of Specialities in Rabat (HSR) in Morocco, over 5 years. Clinical and pathologic findings from hematoxylin and eosin slides and immunohistochemistry for Desmin and Myogenin were reviewed.<BR><B>UNASSIGNED: </B>The median age was 33, with a men's predominance (3 M/2F). Histological analysis revealed three cases of Alveolar Rhabdomyosarcoma (RMS), one Pleomorphic RMS, and one spindle cell/sclerosing RMS. In addition to the typical histology observed in each RMS, we found tricky growth patterns that could be a source of misdiagnosis. All five cases demonstrated variable positivity for Desmin and Myogenin.<BR><B>CONCLUSIONS: </B>HNRMS cases have different pathological features than pediatric RMS cases. We identified rare subtypes such as pleomorphic and spindle cell/sclerotic RMS, which exhibit unusual morphological patterns.