Abstract：
Metabolic diseases are a group of disorders caused by metabolic abnormalities, including obesity, diabetes, non-alcoholic fatty liver disease, and more. Increasing research indicates that, beyond inherent metabolic irregularities, the onset and progression of metabolic diseases are closely linked to alterations in the gut microbiota, particularly gut bacteria. Additionally, fecal microbiota transplantation (FMT) has demonstrated effectiveness in clinically treating metabolic diseases, notably diabetes. Recent attention has also focused on the role of gut viruses in disease onset. This review first introduces the characteristics and influencing factors of gut viruses, then summarizes their potential mechanisms in disease development, highlighting their impact on gut bacteria and regulation of host immunity. We also compare FMT, fecal filtrate transplantation (FFT), washed microbiota transplantation (WMT), and fecal virome transplantation (FVT). Finally, we review the current understanding of gut viruses in metabolic diseases and the application of FVT in treating these conditions. In conclusion, FVT may provide a novel and promising treatment approach for metabolic diseases, warranting further validation through basic and clinical research.
摘要：
代谢性疾病是一组由代谢异常引起的疾病，包括肥胖,糖尿病,非酒精性脂肪性肝病,还有更多.越来越多的研究表明,除了固有的代谢不规则性，代谢性疾病的发生和发展与肠道微生物群的变化密切相关，尤其是肠道细菌。此外,粪便微生物移植（FMT）已证明在临床治疗代谢性疾病的有效性，尤其是糖尿病。最近的注意力也集中在肠道病毒在疾病发作中的作用上。本文首先介绍了肠道病毒的特点和影响因素,然后总结了它们在疾病发展中的潜在机制，强调它们对肠道细菌和宿主免疫调节的影响。我们还比较了FMT，粪便滤液移植（FFT），洗涤微生物群移植(WMT)，和粪便病毒移植（FVT）。最后,我们回顾了目前对肠道病毒在代谢性疾病中的认识以及FVT在治疗这些疾病中的应用。总之,FVT可能为代谢性疾病提供一种新颖且有前途的治疗方法。保证通过基础和临床研究进一步验证。
