Abstract：
Despite many efforts, a comprehensive understanding and clarification of the intricate connections within cancer cell metabolism remain elusive. This might pertain to intracellular dynamics and the complex interplay between cancer cells, and cells with the tumor stroma. Almost a century ago, Otto Warburg found that cancer cells exhibit a glycolytic phenotype, which continues to be a subject of thorough investigation. Past and ongoing investigations have demonstrated intricate mechanisms by which tumors modulate their functionality by utilizing extracellular glucose as a substrate, thereby sustaining the essential proliferation of cancer cells. This concept of \"aerobic glycolysis,\" where cancer cells (even in the presence of enough oxygen) metabolize glucose to produce lactate plays a critical role in cancer progression and is regulated by various signaling pathways. Recent research has revealed that the canonical wingless-related integrated site (WNT) pathway promotes aerobic glycolysis, directly and indirectly, thereby influencing cancer development and progression. The present review seeks to gather knowledge about how the WNT/β-catenin pathway influences aerobic glycolysis, referring to relevant studies in different types of cancer. Furthermore, we propose the concept of impeding the glycolytic phenotype of tumors by employing specific inhibitors that target WNT/β-catenin signaling.
摘要：
尽管做出了许多努力,对癌细胞代谢中复杂的联系的全面理解和澄清仍然难以捉摸。这可能与细胞内动力学和癌细胞之间复杂的相互作用有关，和有肿瘤基质的细胞.差不多一个世纪前,OttoWarburg发现癌细胞表现出糖酵解表型，这仍然是一个彻底调查的主题。过去和正在进行的研究已经证明了肿瘤通过利用细胞外葡萄糖作为底物来调节其功能的复杂机制。从而维持癌细胞的基本增殖。这个“有氧糖酵解”的概念，“癌细胞（即使在有足够的氧气存在下）代谢葡萄糖以产生乳酸在癌症进展中起着关键作用，并受到各种信号通路的调节。最近的研究表明，典型的无翼相关整合位点（WNT）途径促进有氧糖酵解，直接和间接,从而影响癌症的发展和进展。本综述旨在收集有关WNT/β-catenin途径如何影响有氧糖酵解的知识，参考不同类型癌症的相关研究。此外，我们提出了通过使用靶向WNT/β-catenin信号传导的特异性抑制剂来阻止肿瘤糖酵解表型的概念。
