Abstract：
OBJECTIVE: Heart transplant is the most effective treatment in patients with advanced heart failure who are refractory to medical treatment. The brain death interval and type of inotrope We assessed the effects of these parameters on heart transplant outcomes.
METHODS: In this follow-up study, we followed heart transplant recipients for 1 year to study patient survival, ejection fraction, adverse events, and organ rejection. We evaluated follow-up results on time from brainstem death test to the cross-clamp placement, as well as the type of inotrope used.
RESULTS: Our study enrolled 54 heart transplant candidates. The inotrope dose was 3.66 ± 0.99 μg/kg/min, and the most used inotrope, with 28 cases (51.9%), was related to dopamine. Six cases (11.1%) of death and 1 case of infection after transplant were observed in recipients. The average ejection fraction of transplanted hearts before transplant, instantly at time of transplant, and 1 month, 6 months, and 1 year after transplant was 54.9 ± 0.68, 52.9 ± 10.4, 51.9 ± 10.7, 50.1 ± 10.9, and 46.8 ± 17, respectively; this decreasing trend over time was significant (P =.001). Furthermore, ejection fraction changes following transplant did not differ significantly in transplanted hearts regarding brain death interval and type of inotrope used.
CONCLUSIONS: Our study revealed that cardiac output of a transplanted heart may decrease over time and the time elapsed from brain death, and both dopamine and norepinephrine could have negligible effects on cardiac function.
METHODS: In this follow-up study, we followed heart transplant recipients for 1 year to study patient survival, ejection fraction, adverse events, and organ rejection. We evaluated follow-up results on time from brainstem death test to the cross-clamp placement, as well as the type of inotrope used.
RESULTS: Our study enrolled 54 heart transplant candidates. The inotrope dose was 3.66 ± 0.99 μg/kg/min, and the most used inotrope, with 28 cases (51.9%), was related to dopamine. Six cases (11.1%) of death and 1 case of infection after transplant were observed in recipients. The average ejection fraction of transplanted hearts before transplant, instantly at time of transplant, and 1 month, 6 months, and 1 year after transplant was 54.9 ± 0.68, 52.9 ± 10.4, 51.9 ± 10.7, 50.1 ± 10.9, and 46.8 ± 17, respectively; this decreasing trend over time was significant (P =.001). Furthermore, ejection fraction changes following transplant did not differ significantly in transplanted hearts regarding brain death interval and type of inotrope used.
CONCLUSIONS: Our study revealed that cardiac output of a transplanted heart may decrease over time and the time elapsed from brain death, and both dopamine and norepinephrine could have negligible effects on cardiac function.
摘要：
目的：对于药物治疗难以治疗的晚期心力衰竭患者，心脏移植是最有效的治疗方法。脑死亡间隔时间和肌力物质的类型我们评估了这些参数对心脏移植结果的影响。
方法：在这项后续研究中，我们追踪心脏移植受者1年来研究患者的生存率,射血分数,不良事件,和器官排斥。我们评估了从脑干死亡测试到交叉钳放置的时间的随访结果，以及使用的inotrope的类型。
结果：我们的研究招募了54名心脏移植候选人。Inotrope剂量为3.66±0.99μg/kg/min，和最常用的Inotrope，28例(51.9%)，与多巴胺有关.受者移植后死亡6例(11.1%)，感染1例。移植前心脏的平均射血分数，在移植时立即，1个月,6个月,移植后1年分别为54.9±0.68、52.9±10.4、51.9±10.7、50.1±10.9和46.8±17；这种随时间的下降趋势是显著的(P=.001)。此外，移植后的射血分数变化在脑死亡间隔和使用的Inotrope类型方面在移植心脏中没有显着差异。
结论：我们的研究表明，移植心脏的心输出量可能会随着时间和脑死亡时间的推移而减少，多巴胺和去甲肾上腺素对心脏功能的影响可以忽略不计。
方法：在这项后续研究中，我们追踪心脏移植受者1年来研究患者的生存率,射血分数,不良事件,和器官排斥。我们评估了从脑干死亡测试到交叉钳放置的时间的随访结果，以及使用的inotrope的类型。
结果：我们的研究招募了54名心脏移植候选人。Inotrope剂量为3.66±0.99μg/kg/min，和最常用的Inotrope，28例(51.9%)，与多巴胺有关.受者移植后死亡6例(11.1%)，感染1例。移植前心脏的平均射血分数，在移植时立即，1个月,6个月,移植后1年分别为54.9±0.68、52.9±10.4、51.9±10.7、50.1±10.9和46.8±17；这种随时间的下降趋势是显著的(P=.001)。此外，移植后的射血分数变化在脑死亡间隔和使用的Inotrope类型方面在移植心脏中没有显着差异。
结论：我们的研究表明，移植心脏的心输出量可能会随着时间和脑死亡时间的推移而减少，多巴胺和去甲肾上腺素对心脏功能的影响可以忽略不计。
