PDF(Pubmed)
Abstract：
Post-traumatic stress disorder (PTSD) is associated with increased cardiovascular disease (CVD) risk. Compared with males, females are twice as likely to develop PTSD after trauma exposure, and cardiovascular reactivity to stress is a known risk factor for CVD. We aimed to examine hemodynamic responses to acute mental stress in trauma-exposed females with and without a clinical diagnosis of PTSD. We hypothesized that females with PTSD would have higher heart rate (HR), blood pressure (BP), and lower blood flow velocity (BFV) responsiveness compared with controls. We enrolled 21 females with PTSD and 21 trauma-exposed controls. We continuously measured HR using a three-lead electrocardiogram, BP using finger plethysmography, and brachial BFV using Doppler ultrasound. All variables were recorded during 10 min of supine rest, 5 min of mental arithmetic, and 5 min of recovery. Females with PTSD were older, and had higher BMI and higher resting diastolic BP. Accordingly, age, BMI, and diastolic BP were covariates for all repeated measures analyses. Females with PTSD had a blunted brachial BFV response to mental stress (time × group, p = 0.005) compared with controls, suggesting greater vasoconstriction. HR and BP responses were comparable. In conclusion, our results suggest early impairment of vascular function in premenopausal females with PTSD.
摘要：
创伤后应激障碍（PTSD）与心血管疾病（CVD）风险增加有关。与男性相比，女性创伤暴露后患创伤后应激障碍的可能性是女性的两倍，心血管对压力的反应性是心血管疾病的已知危险因素。我们旨在检查有或没有PTSD临床诊断的创伤暴露女性对急性精神压力的血液动力学反应。我们假设患有PTSD的女性会有更高的心率(HR)，血压（BP），与对照组相比，血流速度（BFV）反应性较低。我们招募了21名患有PTSD的女性和21名创伤暴露的对照。我们用三导联心电图连续测量心率,使用手指体积描记术的血压，和使用多普勒超声的肱BFV。在仰卧休息10分钟期间记录所有变量，5分钟的心算，和5分钟的恢复。患有创伤后应激障碍的女性年龄较大，有较高的BMI和较高的静息舒张压。因此，年龄,BMI,和舒张压血压是所有重复测量分析的协变量。患有PTSD的女性对精神压力的肱BFV反应迟钝（时间×组，p=0.005)与对照组相比，提示血管收缩更大.HR和BP反应相当。总之,我们的结果提示绝经前女性PTSD患者血管功能早期受损.
